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Inhibitors of HIV‑1 Attachment: The Discovery and Development of Temsavir and its Prodrug Fostemsavir

Journal of medicinal chemistry, 2018-01, Vol.61 (1), p.62-80

2018

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Phosphonooxymethyl Prodrug of Triptolide: Synthesis, Physicochemical Characterization, and Efficacy in Human Colon Adenocarcinoma and Ovarian Cancer Xenografts

Journal of medicinal chemistry, 2015-12, Vol.58 (23), p.9334-9344

2015

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Design, Synthesis, and Preclinical Evaluation of New 5,6- (or 6,7-) Disubstituted-2-(fluorophenyl)quinolin-4-one Derivatives as Potent Antitumor Agents

Journal of medicinal chemistry, 2010-11, Vol.53 (22), p.8047-8058

2010

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Synthesis and Biological Evaluation of (E)‑4-Hydroxy-3-methylbut-2-enyl Phosphate (HMBP) Aryloxy Triester Phosphoramidate Prodrugs as Activators of Vγ9/Vδ2 T‑Cell Immune Responses

Journal of medicinal chemistry, 2018-03, Vol.61 (5), p.2111-2117

2018

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Novel Immunomodulator FTY720 Is Phosphorylated in Rats and Humans To Form a Single Stereoisomer. Identification, Chemical Proof, and Biological Characterization of the Biologically Active Species and Its Enantiomer

Journal of medicinal chemistry, 2005-08, Vol.48 (16), p.5373-5377

2005

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Structural Evidence That Human Acetylcholinesterase Inhibited by Tabun Ages through O-Dealkylation

Journal of medicinal chemistry, 2010-05, Vol.53 (10), p.4002-4008

2010

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Design of a Potent Reactivator of Tabun-Inhibited AcetylcholinesteraseSynthesis and Evaluation of (E)-1-(4-Carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene Dibromide (K203)

Journal of medicinal chemistry, 2007-11, Vol.50 (22), p.5514-5518

2007

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Discovery of Novel and Potent Thiazoloquinazolines as Selective Aurora A and B Kinase Inhibitors

Journal of medicinal chemistry, 2006-02, Vol.49 (3), p.955-970

2006

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Antineoplastic Agents. 465. Structural Modification of Resveratrol: Sodium Resverastatin Phosphate

Journal of medicinal chemistry, 2002-06, Vol.45 (12), p.2534-2542

2002

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Enzymatically Activated cycloSal-d4T-monophosphates: The Third Generation of cycloSal-Pronucleotides

Journal of medicinal chemistry, 2007-04, Vol.50 (7), p.1658-1667

2007

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Synthesis, in Vitro Evaluation, and Antileishmanial Activity of Water-Soluble Prodrugs of Buparvaquone

Journal of medicinal chemistry, 2004-01, Vol.47 (1), p.188-195

2004

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A Prodrug Approach toward the Development of Water Soluble Fluoroquinolones and Structure−Activity Relationships of Quinoline-3-carboxylic Acids

Journal of medicinal chemistry, 2004-09, Vol.47 (19), p.4693-4709

2004

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Effects of Introduction of Hydrophobic Group on Ribavirin Base on Mutation Induction and Anti-RNA Viral Activity

Journal of medicinal chemistry, 2008-01, Vol.51 (1), p.159-166

2008

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Inhibition of Geranylgeranyl Diphosphate Synthase by Bisphosphonates and Diphosphates: A Potential Route to New Bone Antiresorption and Antiparasitic Agents

Journal of medicinal chemistry, 2002-05, Vol.45 (11), p.2185-2196

2002

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Selective Irreversible Inhibition of Fructose 1,6-Bisphosphate Aldolase from Trypanosoma brucei

Journal of medicinal chemistry, 2006-03, Vol.49 (5), p.1499-1502

2006

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Synthesis and Evaluation of S-Acyl-2-thioethyl Esters of Modified Nucleoside 5‘-Monophosphates as Inhibitors of Hepatitis C Virus RNA Replication

Journal of medicinal chemistry, 2005-02, Vol.48 (4), p.1199-1210

2005

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SAR and X-ray. A New Approach Combining Fragment-Based Screening and Rational Drug Design: Application to the Discovery of Nanomolar Inhibitors of Src SH2

Journal of medicinal chemistry, 2002-06, Vol.45 (12), p.2379-2387

2002

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A 4‘-C-Ethynyl-2‘,3‘-Dideoxynucleoside Analogue Highlights the Role of the 3‘-OH in Anti-HIV Active 4‘-C-Ethynyl-2‘-deoxy Nucleosides

Journal of medicinal chemistry, 2004-10, Vol.47 (21), p.5041-5048

2004

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Synthesis and Biological Evaluation of Spin-Labeled Alkylphospholipid Analogs

Journal of medicinal chemistry, 2005-10, Vol.48 (20), p.6393-6399

2005

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A Systematic Study of C-Glucoside Trisphosphates as myo-Inositol Trisphosphate Receptor Ligands. Synthesis of β-C-Glucoside Trisphosphates Based on the Conformational Restriction Strategy

Journal of medicinal chemistry, 2006-03, Vol.49 (6), p.1900-1909

2006

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cycloSal-2‘,3‘-dideoxy-2‘,3‘-didehydrothymidine Monophosphate (cycloSal-d4TMP): Synthesis and Antiviral Evaluation of a New d4TMP Delivery System

Journal of medicinal chemistry, 1998-04, Vol.41 (9), p.1417-1427

1998

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Interaction of cycloSal-Pronucleotides with Cholinesterases from Different Origins. A Structure−Activity Relationship

Journal of medicinal chemistry, 2004-05, Vol.47 (11), p.2839-2852

2004

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cycloSal-Pronucleotides of 2‘,3‘-Dideoxyadenosine and 2‘,3‘-Dideoxy-2‘,3‘-didehydroadenosine: Synthesis and Antiviral Evaluation of a Highly Efficient Nucleotide Delivery System

Journal of medicinal chemistry, 1999-05, Vol.42 (9), p.1604-1614

1999

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Inhibitors of HIV‑1 Attachment: The Discovery and Development of Temsavir and its Prodrug Fostemsavir

Phosphonooxymethyl Prodrug of Triptolide: Synthesis, Physicochemical Characterization, and Efficacy in Human Colon Adenocarcinoma and Ovarian Cancer Xenografts

Inhibitors of Human Immunodeficiency Virus Type 1 (HIV-1) Attachment 6. Preclinical and Human Pharmacokinetic Profiling of BMS-663749, a Phosphonooxymethyl Prodrug of the HIV-1 Attachment Inhibitor 2-(4-Benzoyl-1-piperazinyl)-1-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoethanone (BMS-488043)

Design, Synthesis, and Preclinical Evaluation of New 5,6- (or 6,7-) Disubstituted-2-(fluorophenyl)quinolin-4-one Derivatives as Potent Antitumor Agents

Synthesis and Biological Evaluation of (E)‑4-Hydroxy-3-methylbut-2-enyl Phosphate (HMBP) Aryloxy Triester Phosphoramidate Prodrugs as Activators of Vγ9/Vδ2 T‑Cell Immune Responses

Novel Immunomodulator FTY720 Is Phosphorylated in Rats and Humans To Form a Single Stereoisomer. Identification, Chemical Proof, and Biological Characterization of the Biologically Active Species and Its Enantiomer

Structural Evidence That Human Acetylcholinesterase Inhibited by Tabun Ages through O-Dealkylation

Design of a Potent Reactivator of Tabun-Inhibited AcetylcholinesteraseSynthesis and Evaluation of (E)-1-(4-Carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene Dibromide (K203)

Discovery of ((4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carbonyl)(propyl)carbamoyloxy)methyl-2-(4-(phosphonooxy)phenyl)acetate (BMS-751324), a Clinical Prodrug of p38α MAP Kinase Inhibitor

Discovery of Novel and Potent Thiazoloquinazolines as Selective Aurora A and B Kinase Inhibitors

Antineoplastic Agents. 465. Structural Modification of Resveratrol: Sodium Resverastatin Phosphate

Enzymatically Activated cycloSal-d4T-monophosphates: The Third Generation of cycloSal-Pronucleotides

Synthesis, in Vitro Evaluation, and Antileishmanial Activity of Water-Soluble Prodrugs of Buparvaquone

A Prodrug Approach toward the Development of Water Soluble Fluoroquinolones and Structure−Activity Relationships of Quinoline-3-carboxylic Acids

Effects of Introduction of Hydrophobic Group on Ribavirin Base on Mutation Induction and Anti-RNA Viral Activity

Inhibition of Geranylgeranyl Diphosphate Synthase by Bisphosphonates and Diphosphates: A Potential Route to New Bone Antiresorption and Antiparasitic Agents

Selective Irreversible Inhibition of Fructose 1,6-Bisphosphate Aldolase from Trypanosoma brucei

Synthesis and Evaluation of S-Acyl-2-thioethyl Esters of Modified Nucleoside 5‘-Monophosphates as Inhibitors of Hepatitis C Virus RNA Replication

SAR and X-ray. A New Approach Combining Fragment-Based Screening and Rational Drug Design: Application to the Discovery of Nanomolar Inhibitors of Src SH2

A 4‘-C-Ethynyl-2‘,3‘-Dideoxynucleoside Analogue Highlights the Role of the 3‘-OH in Anti-HIV Active 4‘-C-Ethynyl-2‘-deoxy Nucleosides

Synthesis and Biological Evaluation of Spin-Labeled Alkylphospholipid Analogs

A Systematic Study of C-Glucoside Trisphosphates as myo-Inositol Trisphosphate Receptor Ligands. Synthesis of β-C-Glucoside Trisphosphates Based on the Conformational Restriction Strategy

cycloSal-2‘,3‘-dideoxy-2‘,3‘-didehydrothymidine Monophosphate (cycloSal-d4TMP): Synthesis and Antiviral Evaluation of a New d4TMP Delivery System

Interaction of cycloSal-Pronucleotides with Cholinesterases from Different Origins. A Structure−Activity Relationship

cycloSal-Pronucleotides of 2‘,3‘-Dideoxyadenosine and 2‘,3‘-Dideoxy-2‘,3‘-didehydroadenosine: Synthesis and Antiviral Evaluation of a Highly Efficient Nucleotide Delivery System

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