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Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor

Nature communications, 2021-06, Vol.12 (1), p.3763-3763, Article 3763

2021

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Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism

Cell research, 2020-05, Vol.30 (5), p.436-445

2020

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Structural insights into the activation of GLP-1R by a small molecule agonist

Cell research, 2020-12, Vol.30 (12), p.1140-1142

2020

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Discovery of TRPM8 Antagonist (S)‑6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine

Journal of medicinal chemistry, 2018-09, Vol.61 (18), p.8186-8201

2018

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Author Correction: Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism

Cell research, 2020-05, Vol.30 (5), p.455-455

2020

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Palladium-Promoted DNA-Compatible Heck Reaction

Organic letters, 2019-02, Vol.21 (3), p.719-723

2019

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Inverse-Electron-Demand Diels–Alder Reactions for the Synthesis of Pyridazines on DNA

Organic letters, 2018-11, Vol.20 (22), p.7186-7191

2018

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753-P: RGT-075, an Orally Efficacious Small Molecule GLP-1R Full Agonist in Cynomolgus Monkey Models

Diabetes (New York, N.Y.), 2022-06, Vol.71 (Supplement_1)

2022

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Direct Construction of Chiral Ether via Highly Efficient Heck Reaction and N‑Directed Asymmetric Hydrogenation for Large-Scale Synthesis of MALT1 Inhibitor RGT-068A

Organic process research & development, 2022-11, Vol.26 (11), p.3089-3095

2022

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Discovery of RGT-018: A Potent, Selective, and Orally Bioavailable SOS1 Inhibitor for KRAS-Driven Cancers

Molecular cancer therapeutics, 2024-08, p.OF1-OF14

2024

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Fragment-Based Computational Method for Designing GPCR Ligands

Journal of chemical information and modeling, 2020-09, Vol.60 (9), p.4339-4349

2020

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Structural insights into ligand recognition and selectivity of somatostatin receptors

Cell research, 2022-08, Vol.32 (8), p.761-772

2022

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Abstract P241: A highly potent HPK1 inhibitor augments immune cell activation and anti-tumor immunity in a syngeneic tumor mouse model

Molecular cancer therapeutics, 2021-12, Vol.20 (12_Supplement), p.P241-P241

2021

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GPCR structure and function relationship: identification of a biased apelin receptor mutant

Biochemical journal, 2018-12, Vol.475 (23), p.3813-3826

2018

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Abstract PS16-22: Targeting resistance to current CDK4/6 therapies by RGT-419B, an inhibitor with optimized kinase activity spectrum

Cancer research (Chicago, Ill.), 2021-02, Vol.81 (4_Supplement), p.PS16-22-PS16-22

2021

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Highly efficient ruthenium-catalyzed asymmetric hydrogenation of N-heteroaryl vinyl ethers

Organic Chemistry Frontiers, 2022-05, Vol.9 (11), p.3022-3026

2022

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Accelerated Discovery of Macrocyclic CDK2 Inhibitor QR-6401 by Generative Models and Structure-Based Drug Design

ACS medicinal chemistry letters, 2023-03, Vol.14 (3), p.297-304

2023

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Structure-guided discovery of a single-domain antibody agonist against human apelin receptor

Science advances, 2020-01, Vol.6 (3), p.eaax7379-eaax7379

2020

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Abstract 477: Discovery of RGT-018: A potent, selective and orally bioavailable SOS1 inhibitor for mutant KRAS-driven cancers

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.477-477

2023

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Synthesis and conformational analysis of α,α-difluoroalkyl heteroaryl ethers

Tetrahedron letters, 2009-09, Vol.50 (39), p.5452-5455

2009

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Abstract 5391: Preclinical evaluation of AMG 337, a highly selective small molecule MET inhibitor, in hepatocellular carcinoma

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.5391-5391

2015

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Fragment Based Drug Discovery: Practical Implementation Based on 19 F NMR Spectroscopy

Journal of medicinal chemistry, 2012-01, Vol.55 (2), p.678-687

2012

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Hydroxyethylamine-based inhibitors of BACE1: P1aP3 macrocyclization can improve potency, selectivity, and cell activity

Bioorganic & medicinal chemistry letters, 2013-08, Vol.23 (15), p.4459-4464

2013

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Structure guided P1a2 modifications of HEA derived beta -secretase inhibitors for the treatment of Alzheimer's disease

Bioorganic & medicinal chemistry letters, 2012-06, Vol.22 (11), p.3607-3611

2012

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A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of β-Secretase

ACS medicinal chemistry letters, 2012-11, Vol.3 (11), p.886-891

2012

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Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor

Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism

Structural insights into the activation of GLP-1R by a small molecule agonist

Discovery of TRPM8 Antagonist (S)‑6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine

Author Correction: Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism

Palladium-Promoted DNA-Compatible Heck Reaction

Inverse-Electron-Demand Diels–Alder Reactions for the Synthesis of Pyridazines on DNA

753-P: RGT-075, an Orally Efficacious Small Molecule GLP-1R Full Agonist in Cynomolgus Monkey Models

Direct Construction of Chiral Ether via Highly Efficient Heck Reaction and N‑Directed Asymmetric Hydrogenation for Large-Scale Synthesis of MALT1 Inhibitor RGT-068A

Discovery of RGT-018: A Potent, Selective, and Orally Bioavailable SOS1 Inhibitor for KRAS-Driven Cancers

Fragment-Based Computational Method for Designing GPCR Ligands

Structural insights into ligand recognition and selectivity of somatostatin receptors

Abstract P241: A highly potent HPK1 inhibitor augments immune cell activation and anti-tumor immunity in a syngeneic tumor mouse model

GPCR structure and function relationship: identification of a biased apelin receptor mutant

Abstract PS16-22: Targeting resistance to current CDK4/6 therapies by RGT-419B, an inhibitor with optimized kinase activity spectrum

Highly efficient ruthenium-catalyzed asymmetric hydrogenation of N-heteroaryl vinyl ethers

Accelerated Discovery of Macrocyclic CDK2 Inhibitor QR-6401 by Generative Models and Structure-Based Drug Design

Structure-guided discovery of a single-domain antibody agonist against human apelin receptor

Abstract 477: Discovery of RGT-018: A potent, selective and orally bioavailable SOS1 inhibitor for mutant KRAS-driven cancers

Synthesis and conformational analysis of α,α-difluoroalkyl heteroaryl ethers

Abstract 5391: Preclinical evaluation of AMG 337, a highly selective small molecule MET inhibitor, in hepatocellular carcinoma

Fragment Based Drug Discovery: Practical Implementation Based on 19 F NMR Spectroscopy

Hydroxyethylamine-based inhibitors of BACE1: P1aP3 macrocyclization can improve potency, selectivity, and cell activity

Structure guided P1a2 modifications of HEA derived beta -secretase inhibitors for the treatment of Alzheimer's disease

A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of β-Secretase

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