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Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation

Cell, 2020-10, Vol.183 (2), p.490-502.e18

2020

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Palladium-Catalyzed Difluoromethylation of Aryl Chlorides and Triflates and Its Applications in the Preparation of Difluoromethylated Derivatives of Drug/Agrochemical Molecules

Journal of organic chemistry, 2018-01, Vol.83 (2), p.1077-1083

2018

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Recent advances in syntheses of heterocycles and carbocycles via homogeneous gold catalysis. Part 1: Heteroatom addition and hydroarylation reactions of alkynes, allenes, and alkenes

Tetrahedron, 2008-04, Vol.64 (18), p.3885-3903

Shen, Hong C.

2008

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Recent advances in syntheses of carbocycles and heterocycles via homogeneous gold catalysis. Part 2: Cyclizations and cycloadditions

Tetrahedron, 2008-08, Vol.64 (34), p.7847-7870

Shen, Hong C.

2008

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Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP–TEAD Protein–Protein Interaction

ACS medicinal chemistry letters, 2014-09, Vol.5 (9), p.993-998

2014

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Divergent copper-mediated dimerization and hydroxylation of benzamides involving C-H bond functionalization

Organic & biomolecular chemistry, 2016-01, Vol.14 (18), p.4239-4246

2016

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Asymmetric synthesis of chiral chromans

Tetrahedron, 2009-05, Vol.65 (20), p.3931-3952

Shen, Hong C.

2009

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Discovery of 3‑Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors

Journal of medicinal chemistry, 2020-07, Vol.63 (13), p.6876-6897

2020

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Discovery of Imidazopyridine Derivatives as Highly Potent Respiratory Syncytial Virus Fusion Inhibitors

ACS medicinal chemistry letters, 2015-03, Vol.6 (3), p.359-362

2015

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Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors

ACS medicinal chemistry letters, 2016-08, Vol.7 (8), p.802-806

2016

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Discovery of Piperazinylquinoline Derivatives as Novel Respiratory Syncytial Virus Fusion Inhibitors

ACS medicinal chemistry letters, 2016-06, Vol.7 (6), p.558-562

2016

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Synthesis of Bridged Bicyclic Morpholine Amino Acids as Compact Modules for Medicinal Chemistry

Chemistry letters, 2017, Vol.46 (4), p.566-568

2017

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Synthesis of novel and conformationally constrained bridged amino acids as compact modules for drug discovery

Tetrahedron letters, 2016-02, Vol.57 (5), p.599-602

2016

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Small molecule approaches to treat autoimmune and inflammatory diseases (Part I): Kinase inhibitors

Bioorganic & medicinal chemistry letters, 2021-04, Vol.38, p.127862-127862, Article 127862

2021

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Highly Chemo- and Regioselective Vinylation of N‑Heteroarenes with Vinylsulfonium Salts

Journal of organic chemistry, 2018-08, Vol.83 (15), p.8627-8635

2018

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Discovery of Ziresovir as a Potent, Selective, and Orally Bioavailable Respiratory Syncytial Virus Fusion Protein Inhibitor

Journal of medicinal chemistry, 2019-07, Vol.62 (13), p.6003-6014

2019

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Synthesis of NH‐Sulfoximines by Using Recyclable Hypervalent Iodine(III) Reagents under Aqueous Micellar Conditions

ChemSusChem, 2020-03, Vol.13 (5), p.922-928

2020

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Constructing Tricyclic Compounds Containing a Seven-Membered Ring by Ruthenium-Catalyzed Intramolecular [5+2] Cycloaddition

Angewandte Chemie International Edition, 2001-06, Vol.40 (12), p.2313-2316

2001

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Discovery of RG7834: The First-in-Class Selective and Orally Available Small Molecule Hepatitis B Virus Expression Inhibitor with Novel Mechanism of Action

Journal of medicinal chemistry, 2018-12, Vol.61 (23), p.10619-10634

2018

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Discovery of 4,5,6,7-Tetrahydropyrazolo[1.5-a]pyrizine Derivatives as Core Protein Allosteric Modulators (CpAMs) for the Inhibition of Hepatitis B Virus

Journal of medicinal chemistry, 2023-10, Vol.66 (20), p.14116-14132

2023

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De novo synthesis, structural assignment and biological evaluation of pseudopaline, a metallophore produced by Pseudomonas aeruginosa

Chemical science (Cambridge), 2019-07, Vol.10 (27), p.6635-6641

2019

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C–H Bond Functionalization of Tetrahydropyridopyrimidines and Other Related Hetereocycles

Journal of organic chemistry, 2017-12, Vol.82 (24), p.13678-13685

2017

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Discovery of Benzoazepinequinoline (BAQ) Derivatives as Novel, Potent, Orally Bioavailable Respiratory Syncytial Virus Fusion Inhibitors

Journal of medicinal chemistry, 2018-11, Vol.61 (22), p.10228-10241

2018

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Asymmetric Synthesis and Application of Homologous Pyrroline-2-alkylboronic Acids: Identification of the B-N Distance for Eliciting Bifunctional Catalysis of an Asymmetric Aldol Reaction

Asian journal of organic chemistry, 2014-04, Vol.3 (4), p.470-479

2014

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Potassium Iodide-Promoted One-Pot Synthesis of Fluoroalkylated Quinoxalines via a Tandem Michael Addition/Azidation/Cycloamination Approach

Journal of organic chemistry, 2018-08, Vol.83 (16), p.9422-9429

2018

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Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation

Palladium-Catalyzed Difluoromethylation of Aryl Chlorides and Triflates and Its Applications in the Preparation of Difluoromethylated Derivatives of Drug/Agrochemical Molecules

Recent advances in syntheses of heterocycles and carbocycles via homogeneous gold catalysis. Part 1: Heteroatom addition and hydroarylation reactions of alkynes, allenes, and alkenes

Recent advances in syntheses of carbocycles and heterocycles via homogeneous gold catalysis. Part 2: Cyclizations and cycloadditions

Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP–TEAD Protein–Protein Interaction

Divergent copper-mediated dimerization and hydroxylation of benzamides involving C-H bond functionalization

Asymmetric synthesis of chiral chromans

Discovery of 3‑Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors

Discovery of Imidazopyridine Derivatives as Highly Potent Respiratory Syncytial Virus Fusion Inhibitors

Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors

Discovery of Piperazinylquinoline Derivatives as Novel Respiratory Syncytial Virus Fusion Inhibitors

Synthesis of Bridged Bicyclic Morpholine Amino Acids as Compact Modules for Medicinal Chemistry

Synthesis of novel and conformationally constrained bridged amino acids as compact modules for drug discovery

Small molecule approaches to treat autoimmune and inflammatory diseases (Part I): Kinase inhibitors

Highly Chemo- and Regioselective Vinylation of N‑Heteroarenes with Vinylsulfonium Salts

Discovery of Ziresovir as a Potent, Selective, and Orally Bioavailable Respiratory Syncytial Virus Fusion Protein Inhibitor

Synthesis of NH‐Sulfoximines by Using Recyclable Hypervalent Iodine(III) Reagents under Aqueous Micellar Conditions

Constructing Tricyclic Compounds Containing a Seven-Membered Ring by Ruthenium-Catalyzed Intramolecular [5+2] Cycloaddition

Discovery of RG7834: The First-in-Class Selective and Orally Available Small Molecule Hepatitis B Virus Expression Inhibitor with Novel Mechanism of Action

Discovery of 4,5,6,7-Tetrahydropyrazolo[1.5-a]pyrizine Derivatives as Core Protein Allosteric Modulators (CpAMs) for the Inhibition of Hepatitis B Virus

De novo synthesis, structural assignment and biological evaluation of pseudopaline, a metallophore produced by Pseudomonas aeruginosa

C–H Bond Functionalization of Tetrahydropyridopyrimidines and Other Related Hetereocycles

Discovery of Benzoazepinequinoline (BAQ) Derivatives as Novel, Potent, Orally Bioavailable Respiratory Syncytial Virus Fusion Inhibitors

Asymmetric Synthesis and Application of Homologous Pyrroline-2-alkylboronic Acids: Identification of the B-N Distance for Eliciting Bifunctional Catalysis of an Asymmetric Aldol Reaction

Potassium Iodide-Promoted One-Pot Synthesis of Fluoroalkylated Quinoxalines via a Tandem Michael Addition/Azidation/Cycloamination Approach

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