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Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations

Nature reviews. Genetics, 2018-05, Vol.19 (5), p.269

2018

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Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage

PLoS genetics, 2013-09, Vol.9 (9), p.e1003794

2013

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The influence of subclonal resistance mutations on targeted cancer therapy

Nature reviews. Clinical oncology, 2016-06, Vol.13 (6), p.335-347

2016

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Next‐Generation Genotoxicology: Using Modern Sequencing Technologies to Assess Somatic Mutagenesis and Cancer Risk

Environmental and molecular mutagenesis, 2020-01, Vol.61 (1), p.135-151

2020

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Mutational heterogeneity in human cancers: origin and consequences

Annual review of pathology, 2010-01, Vol.5 (1), p.51-75

2010

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Duplex sequencing identifies genomic features that determine susceptibility to benzo(a)pyrene-induced in vivo mutations

BMC genomics, 2022-07, Vol.23 (1), p.542-15, Article 542

2022

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Detecting ultralow-frequency mutations by Duplex Sequencing

Nature protocols, 2014-11, Vol.9 (11), p.2586-2606

2014

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Precancer in ulcerative colitis: the role of the field effect and its clinical implications

Carcinogenesis (New York), 2018-01, Vol.39 (1), p.11-20

2018

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Decreased mitochondrial DNA mutagenesis in human colorectal cancer

PLoS genetics, 2012-06, Vol.8 (6), p.e1002689

2012

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Ultra-Sensitive TP53 Sequencing for Cancer Detection Reveals Progressive Clonal Selection in Normal Tissue over a Century of Human Lifespan

Cell reports (Cambridge), 2019-07, Vol.28 (1), p.132-144.e3

2019

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Quantification of measurable residual disease using duplex sequencing in adults with acute myeloid leukemia

Haematologica (Roma), 2024-02, Vol.109 (2), p.401-410

2024

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Targeted genome fragmentation with CRISPR/Cas9 enables fast and efficient enrichment of small genomic regions and ultra-accurate sequencing with low DNA input (CRISPR-DS)

Genome research, 2018-10, Vol.28 (10), p.1589

2018

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Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing

Nature reviews. Drug discovery, 2023-03, Vol.22 (3), p.165-166

2023

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Duplex sequencing provides detailed characterization of mutation frequencies and spectra in the bone marrow of MutaMouse males exposed to procarbazine hydrochloride

Archives of toxicology, 2023-08, Vol.97 (8), p.2245-2259

2023

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Next Generation Sequencing Workshop at the Royal Society of Medicine (London, May 2022): how genomics is on the path to modernizing genetic toxicology

Mutagenesis, 2023-08, Vol.38 (4), p.192-200

2023

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Error-corrected duplex sequencing enables direct detection and quantification of mutations in human TK6 cells with strong inter-laboratory consistency

Mutation research. Genetic toxicology and environmental mutagenesis, 2023-07, Vol.889, p.503649-503649, Article 503649

2023

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Error-corrected next generation sequencing – Promises and challenges for genotoxicity and cancer risk assessment

Mutation research. Reviews in mutation research, 2023-07, Vol.792, p.108466-108466, Article 108466

2023

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Adopting duplex sequencing technology for genetic toxicity testing: A proof-of-concept mutagenesis experiment with N-ethyl-N-nitrosourea (ENU)-exposed rats

Mutation research. Genetic toxicology and environmental mutagenesis, 2023-10, Vol.891, p.503669-503669, Article 503669

2023

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Cancer Genome Sequencing—An Interim Analysis

Cancer research (Chicago, Ill.), 2009-06, Vol.69 (12), p.4948-4950

2009

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Ultra-accurate Duplex Sequencing for the assessment of pretreatment ABL1 kinase domain mutations in Ph+ ALL

Blood cancer journal (New York), 2020-05, Vol.10 (5), p.61-61, Article 61

2020

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Passenger mutations as a marker of clonal cell lineages in emerging neoplasia

Seminars in cancer biology, 2010-10, Vol.20 (5), p.294-303

2010

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Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer

Genome medicine, 2016-03, Vol.8 (1), p.30-30, Article 30

2016

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Response to: ‘when man got his mtDNA deletions?’

Aging cell, 2014-08, Vol.13 (4), p.583-583

2014

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Clonal expansions and short telomeres are associated with neoplasia in early-onset, but not late-onset, ulcerative colitis

Inflammatory bowel diseases, 2013-11, Vol.19 (12), p.2593-2602

2013

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Generation, function, and prognostic utility of somatic mitochondrial DNA mutations in cancer

Environmental and molecular mutagenesis, 2010-06, Vol.51 (5), p.427-439

2010

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Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations

Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage

The influence of subclonal resistance mutations on targeted cancer therapy

Next‐Generation Genotoxicology: Using Modern Sequencing Technologies to Assess Somatic Mutagenesis and Cancer Risk

Mutational heterogeneity in human cancers: origin and consequences

Duplex sequencing identifies genomic features that determine susceptibility to benzo(a)pyrene-induced in vivo mutations

Detecting ultralow-frequency mutations by Duplex Sequencing

Precancer in ulcerative colitis: the role of the field effect and its clinical implications

Decreased mitochondrial DNA mutagenesis in human colorectal cancer

Ultra-Sensitive TP53 Sequencing for Cancer Detection Reveals Progressive Clonal Selection in Normal Tissue over a Century of Human Lifespan

Quantification of measurable residual disease using duplex sequencing in adults with acute myeloid leukemia

Targeted genome fragmentation with CRISPR/Cas9 enables fast and efficient enrichment of small genomic regions and ultra-accurate sequencing with low DNA input (CRISPR-DS)

Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing

Duplex sequencing provides detailed characterization of mutation frequencies and spectra in the bone marrow of MutaMouse males exposed to procarbazine hydrochloride

Next Generation Sequencing Workshop at the Royal Society of Medicine (London, May 2022): how genomics is on the path to modernizing genetic toxicology

Error-corrected duplex sequencing enables direct detection and quantification of mutations in human TK6 cells with strong inter-laboratory consistency

Error-corrected next generation sequencing – Promises and challenges for genotoxicity and cancer risk assessment

Adopting duplex sequencing technology for genetic toxicity testing: A proof-of-concept mutagenesis experiment with N-ethyl-N-nitrosourea (ENU)-exposed rats

Cancer Genome Sequencing—An Interim Analysis

Ultra-accurate Duplex Sequencing for the assessment of pretreatment ABL1 kinase domain mutations in Ph+ ALL

Passenger mutations as a marker of clonal cell lineages in emerging neoplasia

Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer

Response to: ‘when man got his mtDNA deletions?’

Clonal expansions and short telomeres are associated with neoplasia in early-onset, but not late-onset, ulcerative colitis

Generation, function, and prognostic utility of somatic mitochondrial DNA mutations in cancer

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