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The mechanistic basis of prostacyclin and its stable analogues in pulmonary arterial hypertension: Role of membrane versus nuclear receptors

Prostaglandins & other lipid mediators, 2015-07, Vol.120, p.56-71

2015

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Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and iloprost, at human prostanoid receptors: Treprostinil is a potent DP1 and EP2 agonist

Biochemical pharmacology, 2012-07, Vol.84 (1), p.68-75

2012

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Thomas (Tom) B. Bolton – a major force in smooth muscle research

The Journal of physiology, 2024-08, Vol.602 (15), p.3601-3604

2024

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International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E2 Receptors (EP1–4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions

Pharmacological reviews, 2020-10, Vol.72 (4), p.910-968

2020

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Prostanoid EP₂ Receptors Are Up-Regulated in Human Pulmonary Arterial Hypertension: A Key Anti-Proliferative Target for Treprostinil in Smooth Muscle Cells

International journal of molecular sciences, 2018-08, Vol.19 (8), p.2372

2018

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International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E 2 Receptors (EP1-4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions

Pharmacological reviews, 2020-10, Vol.72 (4), p.910-968

2020

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Vasopressin: Mechanisms of action on the vasculature in health and in septic shock

Critical care medicine, 2007-01, Vol.35 (1), p.33-40

2007

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Smooth Muscle Proliferation and Role of the Prostacyclin (IP) Receptor in Idiopathic Pulmonary Arterial Hypertension

American journal of respiratory and critical care medicine, 2010-11, Vol.182 (9), p.1161-1170

2010

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Relative Recovery of Non-Alcoholic Fatty Liver Disease (NAFLD) in Diet-Induced Obese Rats

Nutrients, 2023-12, Vol.16 (1), p.115

2023

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Inhibition of Phosphodiesterase 2 Augments cGMP and cAMP Signaling to Ameliorate Pulmonary Hypertension

Circulation (New York, N.Y.), 2014-08, Vol.130 (6), p.496-507

2014

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Exploring the enzymatic degradation of poly(glycerol adipate)

European journal of pharmaceutics and biopharmaceutics, 2019-09, Vol.142, p.377-386

2019

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Bronchodilation induced by PGE2 is impaired in Group III pulmonary hypertension

British journal of pharmacology, 2020-01, Vol.177 (1), p.161-174

2020

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Prostacyclin mimetics inhibit DRP1-mediated pro-proliferative mitochondrial fragmentation in pulmonary arterial hypertension

Vascular pharmacology, 2023-08, Vol.151, p.107194-107194, Article 107194

2023

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Pharmacology of the single isomer, esuberaprost (beraprost-314d) on pulmonary vascular tone, IP receptors and human smooth muscle proliferation in pulmonary hypertension

Biochemical pharmacology, 2019-08, Vol.166, p.242-252

2019

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Altered cyclooxygenase-1 and enhanced thromboxane receptor activities underlie attenuated endothelial dilatory capacity of omental arteries in obesity

Life sciences (1973), 2019-12, Vol.239, p.117039-117039, Article 117039

2019

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The Prostacyclin Analogue, Treprostinil, Used in the Treatment of Pulmonary Arterial Hypertension, is a Potent Antagonist of TREK-1 and TREK-2 Potassium Channels

Frontiers in pharmacology, 2021-06, Vol.12, p.705421-705421

2021

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Therapeutic potential of inhibiting histone 3 lysine 27 demethylases: a review of the literature

Clinical epigenetics, 2022-08, Vol.14 (1), p.1-98, Article 98

2022

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Bronchodilation induced by PGE 2 is impaired in Group III pulmonary hypertension

British journal of pharmacology, 2020-01, Vol.177 (1), p.161-174

2020

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Role of prostanoid IP and EP receptors in mediating vasorelaxant responses to PGI₂ analogues in rat tail artery: Evidence for Gᵢ/ₒ modulation via EP₃ receptors

European journal of pharmacology, 2011-03, Vol.654 (3), p.258-265

2011

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Adverse Events of Prostacyclin Mimetics in Pulmonary Arterial Hypertension: A Systematic Review and Meta-Analysis

Journal of clinical medicine, 2019-04, Vol.8 (4), p.481

2019

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Interaction between PGI2 and ET-1 pathways in vascular smooth muscle from Group-III pulmonary hypertension patients

Prostaglandins & other lipid mediators, 2020-02, Vol.146, p.106388-106388, Article 106388

2020

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Role of KATP channels in sepsis

Cardiovascular research, 2006-11, Vol.72 (2), p.220-230

2006

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Selexipag in the management of pulmonary arterial hypertension: an update

Drug, healthcare and patient safety, 2019-08, Vol.11, p.55-64

2019

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The role of microvesicles as biomarkers in the screening of colorectal neoplasm

Cancer medicine (Malden, MA), 2022-08, Vol.11 (15), p.2957-2968

2022

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Inotropic Effects of Prostacyclins on the Right Ventricle Are Abolished in Isolated Rat Hearts With Right-Ventricular Hypertrophy and Failure

Journal of cardiovascular pharmacology, 2017-01, Vol.69 (1), p.1-12

2017

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The mechanistic basis of prostacyclin and its stable analogues in pulmonary arterial hypertension: Role of membrane versus nuclear receptors

Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and iloprost, at human prostanoid receptors: Treprostinil is a potent DP1 and EP2 agonist

Thomas (Tom) B. Bolton – a major force in smooth muscle research

International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E2 Receptors (EP1–4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions

Prostanoid EP₂ Receptors Are Up-Regulated in Human Pulmonary Arterial Hypertension: A Key Anti-Proliferative Target for Treprostinil in Smooth Muscle Cells

International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E 2 Receptors (EP1-4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions

Vasopressin: Mechanisms of action on the vasculature in health and in septic shock

Smooth Muscle Proliferation and Role of the Prostacyclin (IP) Receptor in Idiopathic Pulmonary Arterial Hypertension

Relative Recovery of Non-Alcoholic Fatty Liver Disease (NAFLD) in Diet-Induced Obese Rats

Inhibition of Phosphodiesterase 2 Augments cGMP and cAMP Signaling to Ameliorate Pulmonary Hypertension

Exploring the enzymatic degradation of poly(glycerol adipate)

Bronchodilation induced by PGE2 is impaired in Group III pulmonary hypertension

Prostacyclin mimetics inhibit DRP1-mediated pro-proliferative mitochondrial fragmentation in pulmonary arterial hypertension

Pharmacology of the single isomer, esuberaprost (beraprost-314d) on pulmonary vascular tone, IP receptors and human smooth muscle proliferation in pulmonary hypertension

Altered cyclooxygenase-1 and enhanced thromboxane receptor activities underlie attenuated endothelial dilatory capacity of omental arteries in obesity

The Prostacyclin Analogue, Treprostinil, Used in the Treatment of Pulmonary Arterial Hypertension, is a Potent Antagonist of TREK-1 and TREK-2 Potassium Channels

Therapeutic potential of inhibiting histone 3 lysine 27 demethylases: a review of the literature

Bronchodilation induced by PGE 2 is impaired in Group III pulmonary hypertension

Role of prostanoid IP and EP receptors in mediating vasorelaxant responses to PGI₂ analogues in rat tail artery: Evidence for Gᵢ/ₒ modulation via EP₃ receptors

Adverse Events of Prostacyclin Mimetics in Pulmonary Arterial Hypertension: A Systematic Review and Meta-Analysis

Interaction between PGI2 and ET-1 pathways in vascular smooth muscle from Group-III pulmonary hypertension patients

Role of KATP channels in sepsis

Selexipag in the management of pulmonary arterial hypertension: an update

The role of microvesicles as biomarkers in the screening of colorectal neoplasm

Inotropic Effects of Prostacyclins on the Right Ventricle Are Abolished in Isolated Rat Hearts With Right-Ventricular Hypertrophy and Failure

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