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Phosphoproteomic profiling of T cell acute lymphoblastic leukemia reveals targetable kinases and combination treatment strategies

Nature communications, 2022-02, Vol.13 (1), p.1048-1048, Article 1048

2022

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Comparative biochemical kinase activity analysis identifies rivoceranib as a highly selective VEGFR2 inhibitor

Cancer chemotherapy and pharmacology, 2023-06, Vol.91 (6), p.491-499

2023

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Quantitative proteomic and phosphoproteomic comparison of human colon cancer DLD-1 cells differing in ploidy and chromosome stability

Molecular biology of the cell, 2018-05, Vol.29 (9), p.1031-1047

2018

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New avenues to target Wnt/β-catenin signaling

Drug discovery today, 2011, Vol.16 (1), p.35-41

2011

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Pharmacological validation of TDO as a target for Parkinson’s disease

The FEBS journal, 2021-07, Vol.288 (14), p.4311-4331

2021

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CXCR2 antagonists block the N-Ac-PGP-induced neutrophil influx in the airways of mice, but not the production of the chemokine CXCL1

European journal of pharmacology, 2011-10, Vol.668 (3), p.443-449

2011

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Chemokine cooperativity is caused by competitive glycosaminoglycan binding

The Journal of immunology (1950), 2014-04, Vol.192 (8), p.3908-3914

2014

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Congenital Jaundice in Rats with a Mutation in a Multidrug Resistance- Associated Protein Gene

Science (American Association for the Advancement of Science), 1996-02, Vol.271 (5252), p.1126-1128

1996

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Comparative analysis of drug response and gene profiling of HER2-targeted tyrosine kinase inhibitors

British journal of cancer, 2021-03, Vol.124 (7), p.1249-1259

2021

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A Prospective Cross-Screening Study on G-Protein-Coupled Receptors: Lessons Learned in Virtual Compound Library Design

Journal of medicinal chemistry, 2012-06, Vol.55 (11), p.5311-5325

2012

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High-throughput fluorescence-based screening assays for tryptophan-catabolizing enzymes

Journal of biomolecular screening, 2014-10, Vol.19 (9), p.1266-1274

2014

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N-acetylated Proline–Glycine–Proline induced G-protein dependent chemotaxis of neutrophils is independent of CXCL8 release

European journal of pharmacology, 2011-10, Vol.668 (3), p.428-434

2011

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Noncompetitive antagonism and inverse agonism as mechanism of action of nonpeptidergic antagonists at primate and rodent CXCR3 chemokine receptors

The Journal of pharmacology and experimental therapeutics, 2008-05, Vol.325 (2), p.544

2008

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MAPK-ERK is a central pathway in T-cell acute lymphoblastic leukemia that drives steroid resistance

Leukemia, 2021-12, Vol.35 (12), p.3394-3405

2021

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Ligand-induced folding of the guanine-sensing riboswitch is controlled by a combined predetermined induced fit mechanism

RNA (Cambridge), 2007-12, Vol.13 (12), p.2202-2212

2007

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The bacterial lysate OM-85 engages Toll-like receptors 2 and 4 triggering an immunomodulatory gene signature in human myeloid cells

Mucosal immunology, 2024-06, Vol.17 (3), p.346-358

2024

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The collagen-breakdown product N-acetyl-Proline-Glycine-Proline ( N-α -PGP) does not interact directly with human CXCR1 and CXCR2

European journal of pharmacology, 2010-09, Vol.643 (1), p.29-33

2010

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Compound Selectivity and Target Residence Time of Kinase Inhibitors Studied with Surface Plasmon Resonance

Journal of molecular biology, 2017-02, Vol.429 (4), p.574-586

2017

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TTK Inhibitors as a Targeted Therapy for CTNNB1 ( β -catenin) Mutant Cancers

Molecular cancer therapeutics, 2017-11, Vol.16 (11), p.2609-2617

2017

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Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity

Journal of molecular biology, 2017-07, Vol.429 (14), p.2211-2230

2017

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β-Arrestin-biased signaling of PTH analogs of the type 1 parathyroid hormone receptor

Cellular signalling, 2013-02, Vol.25 (2), p.527-538

2013

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Optimized Target Residence Time: Type I1/2 Inhibitors for p38α MAP Kinase with Improved Binding Kinetics through Direct Interaction with the R‐Spine

Angewandte Chemie International Edition, 2017-05, Vol.56 (19), p.5363-5367

2017

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Combined Cellular and Biochemical Profiling to Identify Predictive Drug Response Biomarkers for Kinase Inhibitors Approved for Clinical Use between 2013 and 2017

Molecular cancer therapeutics, 2019-02, Vol.18 (2), p.470-481

2019

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A model for signaling specificity of Wnt/Frizzled combinations through co-receptor recruitment

FEBS letters, 2010-09, Vol.584 (18), p.3850-3854

2010

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Phosphoproteomic profiling of T cell acute lymphoblastic leukemia reveals targetable kinases and combination treatment strategies

Comparative biochemical kinase activity analysis identifies rivoceranib as a highly selective VEGFR2 inhibitor

Quantitative proteomic and phosphoproteomic comparison of human colon cancer DLD-1 cells differing in ploidy and chromosome stability

New avenues to target Wnt/β-catenin signaling

Pharmacological validation of TDO as a target for Parkinson’s disease

CXCR2 antagonists block the N-Ac-PGP-induced neutrophil influx in the airways of mice, but not the production of the chemokine CXCL1

Chemokine cooperativity is caused by competitive glycosaminoglycan binding

Congenital Jaundice in Rats with a Mutation in a Multidrug Resistance- Associated Protein Gene

Comparative analysis of drug response and gene profiling of HER2-targeted tyrosine kinase inhibitors

A Prospective Cross-Screening Study on G-Protein-Coupled Receptors: Lessons Learned in Virtual Compound Library Design

High-throughput fluorescence-based screening assays for tryptophan-catabolizing enzymes

N-acetylated Proline–Glycine–Proline induced G-protein dependent chemotaxis of neutrophils is independent of CXCL8 release

Noncompetitive antagonism and inverse agonism as mechanism of action of nonpeptidergic antagonists at primate and rodent CXCR3 chemokine receptors

MAPK-ERK is a central pathway in T-cell acute lymphoblastic leukemia that drives steroid resistance

Ligand-induced folding of the guanine-sensing riboswitch is controlled by a combined predetermined induced fit mechanism

The bacterial lysate OM-85 engages Toll-like receptors 2 and 4 triggering an immunomodulatory gene signature in human myeloid cells

The collagen-breakdown product N-acetyl-Proline-Glycine-Proline ( N-α -PGP) does not interact directly with human CXCR1 and CXCR2

Compound Selectivity and Target Residence Time of Kinase Inhibitors Studied with Surface Plasmon Resonance

TTK Inhibitors as a Targeted Therapy for CTNNB1 ( β -catenin) Mutant Cancers

Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity

β-Arrestin-biased signaling of PTH analogs of the type 1 parathyroid hormone receptor

Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines

Optimized Target Residence Time: Type I1/2 Inhibitors for p38α MAP Kinase with Improved Binding Kinetics through Direct Interaction with the R‐Spine

Combined Cellular and Biochemical Profiling to Identify Predictive Drug Response Biomarkers for Kinase Inhibitors Approved for Clinical Use between 2013 and 2017

A model for signaling specificity of Wnt/Frizzled combinations through co-receptor recruitment

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