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The clinical progress of mRNA vaccines and immunotherapies

Nature biotechnology, 2022-06, Vol.40 (6), p.840-854

2022

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Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency

The New England journal of medicine, 2019-09, Vol.381 (10), p.933-944

2019

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A phase I/II study of intrathecal idursulfase-IT in children with severe mucopolysaccharidosis II

Genetics in medicine, 2016-01, Vol.18 (1), p.73-81

2016

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A phase 1/2 study of intrathecal heparan-N-sulfatase in patients with mucopolysaccharidosis IIIA

Molecular genetics and metabolism, 2016-07, Vol.118 (3), p.198-205

2016

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Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms

British journal of pharmacology, 2006-05, Vol.148 (1), p.102-113

2006

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Phase 1 Single‐ and Multiple‐Ascending‐Dose Randomized Studies of the Safety, Pharmacokinetics, and Pharmacodynamics of AG‐348, a First‐in‐Class Allosteric Activator of Pyruvate Kinase R, in Healthy Volunteers

Clinical pharmacology in drug development, 2019-02, Vol.8 (2), p.246-259

2019

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Neurocognitive clinical outcome assessments for inborn errors of metabolism and other rare conditions

Molecular genetics and metabolism, 2016-06, Vol.118 (2), p.65-69

2016

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A novel LC-MS/MS assay for heparan sulfate screening in the cerebrospinal fluid of mucopolysaccharidosis IIIA patients

Bioanalysis, 2016-02, Vol.8 (4), p.285-295

2016

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Patient Voice in Rare Disease Drug Development and Endpoints

Therapeutic innovation & regulatory science, 2017-03, Vol.51 (2), p.257-263

2017

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In-vitro and in-vivo characterization of JNJ-7925476, a novel triple monoamine uptake inhibitor

European journal of pharmacology, 2008-06, Vol.587 (1), p.141-146

2008

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Novel Benzamide-Based Histamine H3 Receptor Antagonists: The Identification of Two Candidates for Clinical Development

ACS medicinal chemistry letters, 2015-04, Vol.6 (4), p.450-454

2015

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A high-throughput-compatible assay for determining the activity of fatty acid amide hydrolase

Analytical biochemistry, 2003-07, Vol.318 (2), p.270-275

2003

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Transmodulation of Epidermal Growth Factor Receptor Function by Cyclic AMP-dependent Protein Kinase

The Journal of biological chemistry, 1999-05, Vol.274 (20), p.14067-14073

1999

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Behavioral Characterization of Mice Lacking Histamine H 3 Receptors

Molecular pharmacology, 2002-08, Vol.62 (2), p.389-397

2002

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Lead identification of acetylcholinesterase inhibitors–histamine H 3 receptor antagonists from molecular modeling

Bioorganic & medicinal chemistry, 2008-03, Vol.16 (6), p.2968-2973

2008

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Functional analyses of type V adenylyl cyclase

Methods in Enzymology, 2002, Vol.345, p.160-187

2002

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A New Class of Diamine-Based Human Histamine H 3 Receptor Antagonists: 4-(Aminoalkoxy)benzylamines

Journal of medicinal chemistry, 2003-08, Vol.46 (18), p.3938-3944

2003

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Development of a prototype reporter-based assay for the evaluation of gap junctional intercellular communication

Biotechnology letters, 2001-10, Vol.23 (19), p.1559-1563

2001

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Relaxant influence of phosphodiesterase inhibitors in the cat gastric fundus

European journal of pharmacology, 1995-03, Vol.276 (1), p.41-47

1995

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Pharmacological characterization of JNJ-28583867, a histamine H 3 receptor antagonist and serotonin reuptake inhibitor

European journal of pharmacology, 2007-12, Vol.576 (1), p.43-54

2007

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4-Phenoxypiperidines: Potent, Conformationally Restricted, Non-Imidazole Histamine H 3 Antagonists

Journal of medicinal chemistry, 2005-03, Vol.48 (6), p.2229-2238

2005

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Heterocyclic replacement of the central phenyl core of diamine-based histamine H 3 receptor antagonists

European journal of medicinal chemistry, 2009-11, Vol.44 (11), p.4413-4425

2009

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Pyrrolidino-tetrahydroisoquinolines bearing pendant heterocycles as potent dual H 3 antagonist and serotonin transporter inhibitors

Bioorganic & medicinal chemistry letters, 2007-08, Vol.17 (15), p.4374-4377

2007

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Dual serotonin transporter/histamine H 3 ligands: Optimization of the H 3 pharmacophore

Bioorganic & medicinal chemistry letters, 2007-02, Vol.17 (3), p.702-706

2007

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Synthesis and biological activity of piperazine and diazepane amides that are histamine H 3 antagonists and serotonin reuptake inhibitors

Bioorganic & medicinal chemistry letters, 2008, Vol.18 (1), p.39-43

2008

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The clinical progress of mRNA vaccines and immunotherapies

Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency

A phase I/II study of intrathecal idursulfase-IT in children with severe mucopolysaccharidosis II

A phase 1/2 study of intrathecal heparan-N-sulfatase in patients with mucopolysaccharidosis IIIA

Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms

Phase 1 Single‐ and Multiple‐Ascending‐Dose Randomized Studies of the Safety, Pharmacokinetics, and Pharmacodynamics of AG‐348, a First‐in‐Class Allosteric Activator of Pyruvate Kinase R, in Healthy Volunteers

Neurocognitive clinical outcome assessments for inborn errors of metabolism and other rare conditions

A novel LC-MS/MS assay for heparan sulfate screening in the cerebrospinal fluid of mucopolysaccharidosis IIIA patients

Patient Voice in Rare Disease Drug Development and Endpoints

In-vitro and in-vivo characterization of JNJ-7925476, a novel triple monoamine uptake inhibitor

Novel Benzamide-Based Histamine H3 Receptor Antagonists: The Identification of Two Candidates for Clinical Development

A high-throughput-compatible assay for determining the activity of fatty acid amide hydrolase

Transmodulation of Epidermal Growth Factor Receptor Function by Cyclic AMP-dependent Protein Kinase

Behavioral Characterization of Mice Lacking Histamine H 3 Receptors

Lead identification of acetylcholinesterase inhibitors–histamine H 3 receptor antagonists from molecular modeling

Functional analyses of type V adenylyl cyclase

A New Class of Diamine-Based Human Histamine H 3 Receptor Antagonists: 4-(Aminoalkoxy)benzylamines

Development of a prototype reporter-based assay for the evaluation of gap junctional intercellular communication

Relaxant influence of phosphodiesterase inhibitors in the cat gastric fundus

Pharmacological characterization of JNJ-28583867, a histamine H 3 receptor antagonist and serotonin reuptake inhibitor

4-Phenoxypiperidines: Potent, Conformationally Restricted, Non-Imidazole Histamine H 3 Antagonists

Heterocyclic replacement of the central phenyl core of diamine-based histamine H 3 receptor antagonists

Pyrrolidino-tetrahydroisoquinolines bearing pendant heterocycles as potent dual H 3 antagonist and serotonin transporter inhibitors

Dual serotonin transporter/histamine H 3 ligands: Optimization of the H 3 pharmacophore

Synthesis and biological activity of piperazine and diazepane amides that are histamine H 3 antagonists and serotonin reuptake inhibitors

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