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5-Cyanopyrimidine Derivatives as a Novel Class of Potent, Selective, and Orally Active Inhibitors of p38α MAP Kinase

Journal of medicinal chemistry, 2005-10, Vol.48 (20), p.6261-6270

2005

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The Discovery of Orally Active Triaminotriazine Aniline Amides as Inhibitors of p38 MAP Kinase

Journal of medicinal chemistry, 2004-12, Vol.47 (25), p.6283-6291

2004

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Inhibition of Tyrosine Phosphorylation Prevents T-Cell Receptor-Mediated Signal Transduction

Proceedings of the National Academy of Sciences - PNAS, 1990-10, Vol.87 (19), p.7722-7726

1990

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Role of oxidative stress in the action of vanadium phosphotyrosine phosphatase inhibitors. Redox independent activation of NF- Kappa B

The Journal of biological chemistry, 1997-04, Vol.272 (17), p.11541-11549

1997

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Interaction of the Cytoplasmic Tail of CTLA-4 (CD152) with a Clathrin-Associated Protein Is Negatively Regulated by Tyrosine Phosphorylation

Biochemistry (Easton), 1997-12, Vol.36 (50), p.15975-15982

1997

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Phosphorylation of the Linker for Activation of T-Cells by Itk Promotes Recruitment of Vav

Biochemistry (Easton), 2002-08, Vol.41 (34), p.10732-10740

2002

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Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase

The Journal of biological chemistry, 1993-11, Vol.268 (32), p.24442-24448

1993

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Syk interacts with tyrosine-phosphorylated proteins in human platelets activated by collagen and cross-linking of the Fc gamma-IIA receptor

Biochemical journal, 1995-10, Vol.311 ( Pt 2) (2), p.471-478

1995

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p72syk tyrosine kinase is activated by oxidizing conditions that induce lymphocyte tyrosine phosphorylation and Ca2+ signals

The Journal of biological chemistry, 1993-08, Vol.268 (22), p.16688-16692

1993

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Impact of Oxidative Stress on Signal Transduction Control by Phosphotyrosine Phosphatases

Environmental health perspectives, 1998-10, Vol.106, p.1179

1998

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Cloning and Expression of the Tumor-Associated Antigen L6

Proceedings of the National Academy of Sciences - PNAS, 1992-04, Vol.89 (8), p.3503-3507

1992

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Longitudinal exposure of human T lymphocytes to weak oxidative stress suppresses transmembrane and nuclear signal transduction

The Journal of immunology (1950), 1994-12, Vol.153 (11), p.4880-4889

1994

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Association of 75/80-kDa phosphoproteins and the tyrosine kinases Lyn, Fyn, and Lck with the B cell molecule CD20. Evidence against involvement of the cytoplasmic regions of CD20

The Journal of biological chemistry, 1995-09, Vol.270 (38), p.22632-22638

1995

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Stimulation of protein tyrosine phosphorylation, phosphoinositide turnover, and multiple previously unidentified serine/threonine-specific protein kinases by the Pan-B-cell receptor CD40/Bp50 at discrete developmental stages of human B-cell ontogeny

The Journal of biological chemistry, 1991-09, Vol.266 (26), p.17478-17485

1991

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The role of tyrosine phosphorylation in signal transduction through surface Ig in human B cells. Inhibition of tyrosine phosphorylation prevents intracellular calcium release

The Journal of immunology (1950), 1991-01, Vol.146 (2), p.715-722

1991

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The role of class II molecules in human B cell activation. Association with phosphatidyl inositol turnover, protein tyrosine phosphorylation, and proliferation

The Journal of immunology (1950), 1990-05, Vol.144 (10), p.3684-3692

1990

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CD28 Ligation in T-Cell Activation: Evidence for Two Signal Transduction Pathways

Blood, 1990-04, Vol.75 (7), p.1531-1539

1990

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Association of tyrosine and serine kinases with the B cell surface antigen CD20. Induction via CD20 of tyrosine phosphorylation and activation of phospholipase C-gamma 1 and PLC phospholipase C-gamma 2

The Journal of immunology (1950), 1993-11, Vol.151 (9), p.4494-4504

1993

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CD45 cross-linking regulates phospholipase C activation and tyrosine phosphorylation of specific substrates in CD3/Ti-stimulated T cells

The Journal of immunology (1950), 1991-03, Vol.146 (5), p.1577-1583

1991

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7,12-Dimethylbenz[a]anthracene activates protein-tyrosine kinases Fyn and Lck in the HPB-ALL human T-cell line and increases tyrosine phosphorylation of phospholipase C-gamma 1, formation of inositol 1,4,5-trisphosphate, and mobilization of intracellular calcium

Proceedings of the National Academy of Sciences - PNAS, 1993-07, Vol.90 (13), p.6105-6109

1993

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Interleukin 7 Receptor Ligation Stimulates Tyrosine Phosphorylation, Inositol Phospholipid Turnover, and Clonal Proliferation of Human B-Cell Precursors

Proceedings of the National Academy of Sciences - PNAS, 1991-05, Vol.88 (9), p.3589-3593

1991

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Novel yeast protein kinase (YPK1 gene product) is a 40-kilodalton phosphotyrosyl protein associated with protein-tyrosine kinase activity

Molecular and Cellular Biology, 1990-12, Vol.10 (12), p.6244-6256

1990

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Lineage-specific Induction of B Cell Apoptosis and Altered Signal Transduction by the Phosphotyrosine Phosphatase Inhibitor Bis(maltolato)oxovanadium(IV) (∗)

The Journal of biological chemistry, 1995-09, Vol.270 (35), p.20824-20831

1995

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Lymphocyte lineage-restricted tyrosine-phosphorylated proteins that bind PLC gamma 1 SH2 domains

The Journal of biological chemistry, 1992-07, Vol.267 (19), p.13610-13616

1992

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Discovery of N-(2-Chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a Dual Src/Abl Kinase Inhibitor with Potent Antitumor Activity in Preclinical Assays

5-Cyanopyrimidine Derivatives as a Novel Class of Potent, Selective, and Orally Active Inhibitors of p38α MAP Kinase

The Discovery of Orally Active Triaminotriazine Aniline Amides as Inhibitors of p38 MAP Kinase

Inhibition of Tyrosine Phosphorylation Prevents T-Cell Receptor-Mediated Signal Transduction

Role of oxidative stress in the action of vanadium phosphotyrosine phosphatase inhibitors. Redox independent activation of NF- Kappa B

Interaction of the Cytoplasmic Tail of CTLA-4 (CD152) with a Clathrin-Associated Protein Is Negatively Regulated by Tyrosine Phosphorylation

Phosphorylation of the Linker for Activation of T-Cells by Itk Promotes Recruitment of Vav

Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase

Syk interacts with tyrosine-phosphorylated proteins in human platelets activated by collagen and cross-linking of the Fc gamma-IIA receptor

p72syk tyrosine kinase is activated by oxidizing conditions that induce lymphocyte tyrosine phosphorylation and Ca2+ signals

Impact of Oxidative Stress on Signal Transduction Control by Phosphotyrosine Phosphatases

Cloning and Expression of the Tumor-Associated Antigen L6

Longitudinal exposure of human T lymphocytes to weak oxidative stress suppresses transmembrane and nuclear signal transduction

Association of 75/80-kDa phosphoproteins and the tyrosine kinases Lyn, Fyn, and Lck with the B cell molecule CD20. Evidence against involvement of the cytoplasmic regions of CD20

Stimulation of protein tyrosine phosphorylation, phosphoinositide turnover, and multiple previously unidentified serine/threonine-specific protein kinases by the Pan-B-cell receptor CD40/Bp50 at discrete developmental stages of human B-cell ontogeny

The role of tyrosine phosphorylation in signal transduction through surface Ig in human B cells. Inhibition of tyrosine phosphorylation prevents intracellular calcium release

The role of class II molecules in human B cell activation. Association with phosphatidyl inositol turnover, protein tyrosine phosphorylation, and proliferation

CD28 Ligation in T-Cell Activation: Evidence for Two Signal Transduction Pathways

Association of tyrosine and serine kinases with the B cell surface antigen CD20. Induction via CD20 of tyrosine phosphorylation and activation of phospholipase C-gamma 1 and PLC phospholipase C-gamma 2

CD45 cross-linking regulates phospholipase C activation and tyrosine phosphorylation of specific substrates in CD3/Ti-stimulated T cells

7,12-Dimethylbenz[a]anthracene activates protein-tyrosine kinases Fyn and Lck in the HPB-ALL human T-cell line and increases tyrosine phosphorylation of phospholipase C-gamma 1, formation of inositol 1,4,5-trisphosphate, and mobilization of intracellular calcium

Interleukin 7 Receptor Ligation Stimulates Tyrosine Phosphorylation, Inositol Phospholipid Turnover, and Clonal Proliferation of Human B-Cell Precursors

Novel yeast protein kinase (YPK1 gene product) is a 40-kilodalton phosphotyrosyl protein associated with protein-tyrosine kinase activity

Lineage-specific Induction of B Cell Apoptosis and Altered Signal Transduction by the Phosphotyrosine Phosphatase Inhibitor Bis(maltolato)oxovanadium(IV) (∗)

Lymphocyte lineage-restricted tyrosine-phosphorylated proteins that bind PLC gamma 1 SH2 domains

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