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AKT in cancer: new molecular insights and advances in drug development

British journal of clinical pharmacology, 2016-10, Vol.82 (4), p.943-956

2016

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Zika virus induces massive cytoplasmic vacuolization and paraptosis‐like death in infected cells

The EMBO journal, 2017-06, Vol.36 (12), p.1653-1668

2017

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Alternative activation of macrophages by IL-4 impairs phagocytosis of pathogens but potentiates microbial-induced signalling and cytokine secretion

Blood, 2010-01, Vol.115 (2), p.353-362

2010

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Central Resistin Overexposure Induces Insulin Resistance Through Toll-Like Receptor 4

Diabetes (New York, N.Y.), 2013-01, Vol.62 (1), p.102-114

2013

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Fyn is induced by Ras/PI3K/Akt signaling and is required for enhanced invasion/migration

Molecular carcinogenesis, 2011-05, Vol.50 (5), p.346-352

2011

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PPARγ contributes to PKM2 and HK2 expression in fatty liver

Nature communications, 2012-02, Vol.3 (1), p.672-672, Article 672

2012

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Circular RNA Complement Factor H (CFH) Promotes Glioma Progression by Sponging miR-149 and Regulating AKT1

Medical science monitor, 2018-08, Vol.24, p.5704-5712

2018

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Long Noncoding RNA (lncRNA) FOXD2-AS1 Promotes Cell Proliferation and Metastasis in Hepatocellular Carcinoma by Regulating MiR-185/AKT Axis

Medical science monitor, 2019-12, Vol.25, p.9618-9629

2019

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Low-level laser therapy can produce increased aggressiveness of dysplastic and oral cancer cell lines by modulation of Akt/mTOR signaling pathway

Journal of biophotonics, 2013-10, Vol.6 (10), p.839-847

2013

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Phosphoinositide 3-kinase p110 delta regulates natural antibody production, marginal zone and B-1 B cell function, and autoantibody responses

The Journal of immunology (1950), 2009-11, Vol.183 (9), p.5673-5684

2009

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Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature

Proceedings of the National Academy of Sciences - PNAS, 2012-03, Vol.109 (11), p.4257-4262

2012

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The dual PI3K/mTOR inhibitor NVP‐BEZ235 and chloroquine synergize to trigger apoptosis via mitochondrial‐lysosomal cross‐talk

International journal of cancer, 2013-06, Vol.132 (11), p.2682-2693

2013

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Oridonin Alleviates IRI-Induced Kidney Injury by Inhibiting Inflammatory Response of Macrophages via AKT-Related Pathways

Medical science monitor, 2020-05, Vol.26, p.e921114-e921114-11

2020

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Damage-associated molecular pattern S100A9 increases bactericidal activity of human neutrophils by enhancing phagocytosis

The Journal of immunology (1950), 2011-03, Vol.186 (6), p.3622-3631

2011

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Rab7 Is Associated with Poor Prognosis of Gastric Cancer and Promotes Proliferation, Invasion, and Migration of Gastric Cancer Cells

Medical science monitor, 2020-06, Vol.26, p.e922217-e922217

2020

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miR-18a-5p Promotes Proliferation and Migration of Vascular Smooth Muscle Cells by Activating the AKT/Extracellular Regulated Protein Kinases (ERK) Signaling Pathway

Medical science monitor, 2020-05, Vol.26, p.e924625-e924625

2020

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Nicotine-induced structural plasticity in mesencephalic dopaminergic neurons is mediated by dopamine D3 receptors and Akt-mTORC1 signaling

Molecular pharmacology, 2013-06, Vol.83 (6), p.1176-1189

2013

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Up-Regulation of Phosphatase in Regenerating Liver-3 (PRL-3) Contributes to Malignant Progression of Hepatocellular Carcinoma by Activating Phosphatase and Tensin Homolog Deleted on Chromosome Ten (PTEN)/Phosphoinositide 3-Kinase (PI3K)/AKT Signaling Pathway

Medical science monitor, 2018-11, Vol.24, p.8105-8114

2018

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Downregulation of Akt/mammalian target of rapamycin pathway in skeletal muscle is associated with increased REDD1 expression in response to chronic hypoxia

American journal of physiology. Regulatory, integrative and comparative physiology, 2010-06, Vol.298 (6), p.R1659-R1666

2010

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Curcumin protects neuronal-like cells against acrolein by restoring Akt and redox signaling pathways

Molecular nutrition & food research, 2013-09, Vol.57 (9), p.1660-1670

2013

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PI3Kγ activity in leukocytes promotes adipose tissue inflammation and early-onset insulin resistance during obesity

Science signaling, 2017-07, Vol.10 (488)

2017

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Overexpression of Biglycan is Associated with Resistance to Rapamycin in Human WERI-Rb-1 Retinoblastoma Cells by Inducing the Activation of the Phosphatidylinositol 3-Kinases (PI3K)/Akt/Nuclear Factor kappa B (NF-κB) Signaling Pathway

Medical science monitor, 2019-09, Vol.25, p.6639-6648

2019

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Inhibition of PI3K-Akt signaling blocks exercise-mediated enhancement of adult neurogenesis and synaptic plasticity in the dentate gyrus

PloS one, 2009-11, Vol.4 (11), p.e7901-e7901

2009

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Eriocalyxin B Induces Apoptosis and Autophagy Involving Akt/Mammalian Target of Rapamycin (mTOR) Pathway in Prostate Cancer Cells

Medical science monitor, 2019-11, Vol.25, p.8534-8543

2019

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