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Phosphodiesterase 10A (PDE10A) as a novel target to suppress β-catenin and RAS signaling in epithelial ovarian cancer

Journal of ovarian research, 2022-11, Vol.15 (1), p.120-17, Article 120

2022

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Abstract 326: Discovery and in vitro and in vivo characterization of a novel, small-molecule Ras inhibitor class

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.326-326

2016

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Abstract 1213: PDE10A as a novel target to suppress Wnt/β-catenin signaling and other oncogenic pathways in ovarian cancer

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1213-1213

2021

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Abstract 2731: A novel PDE10/beta-catenin inhibitor, MCI-048, suppresses lung tumorigenesis to block metastasis

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.2731-2731

2019

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Abstract 2707: A novel RAS inhibitor, MCI-062, inhibits colon tumor growth in vivo and activates antitumor immunity

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.2707-2707

2019

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Abstract 345: Novel RAS inhibitor, MCI-062, potently and selectively inhibits the growth of KRAS mutant pancreatic tumor cells by blocking GTP loading of RAS

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.345-345

2019

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Abstract 5166: Sensitivity of melanoma cells to a novel class of Ras inhibitors

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.5166-5166

2017

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Abstract 1937: Inhibition of a novel cancer target, PDE10, suppresses Wnt/β-catenin signaling and colon tumorigenesis: Benefits from combining with ornithine decarboxylase inhibitors

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.1937-1937

2018

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Suppression of Colon Tumorigenesis in Mutant Apc Mice by a Novel PDE10 Inhibitor that Reduces Oncogenic β-Catenin

Cancer prevention research (Philadelphia, Pa.), 2021-11, Vol.14 (11), p.995-1008

2021

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Abstract 4822: Targeting RAS and downstream signaling in high-grade serous ovarian carcinoma with novel RAS inhibitors

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.4822-4822

2019

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Abstract 3864: A novel PDE10/β-catenin pathway inhibitor, MCI-030, for the treatment of colorectal cancer

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.3864-3864

2019

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Abstract B54: Targeting constitutively active RAS signaling in high-grade serous ovarian carcinoma (HGSOC) with ADT-006, a novel small molecule that blocks RAS-effector interactions

Clinical cancer research, 2018-01, Vol.24 (1_Supplement), p.B54-B54

2018

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Genome sequence of the dissimilatory metal ion-reducing bacterium Shewanella oneidensis

Nature biotechnology, 2002-11, Vol.20 (11), p.1118-1123

2002

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Abstract 5174: Phosphodiesterase 10A inhibition as a novel approach to suppress β-catenin signaling in ovarian cancer cells

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.5174-5174

2017

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Abstract 4972: Novel Ras inhibitor DC070-547 potently and selectively blocks Ras-RBD binding, EGFR binding to Ras signaling complex, EGFR activation of Ras signaling, and growth of Ras-driven lung tumor cells

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.4972-4972

2017

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Abstract 5159: Characterization of a novel class of RAS inhibitory compounds with potent anti-tumor activity

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.5159-5159

2017

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Phosphodiesterase 10A (PDE10A) as a novel target to suppress [beta]-catenin and RAS signaling in epithelial ovarian cancer

Journal of ovarian research, 2022-11, Vol.15 (1)

2022

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Abstract 1633: ADT-030, a novel dual-acting RAS and β-catenin inhibitor with robust antitumor activity

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.1633-1633

2023

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Abstract B23: DC070-547, a novel Ras inhibitor potently and selectivity inhibits colon tumor growth in vitro and in vivo

Cancer research (Chicago, Ill.), 2017-02, Vol.77 (3_Supplement), p.B23-B23

2017

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Abstract 1238: A novel Ras inhibitor potently and selectively suppresses lung tumor cell growth by blocking Ras-Raf binding

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.1238-1238

2016

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Abstract 1140: Characterization of a novel PDE10 inhibitor in lung tumor cells and an orthotopic mouse model of lung cancer

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.1140-1140

2017

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Abstract LB322: Antitumor activity of 1st-in-class pan-RAS inhibitor ADT-1004 in mouse models of pancreatic ductal adenocarcinoma

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (8_Supplement), p.LB322-LB322

2023

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Abstract 1658: ADT-007 binds RAS and inhibits RAS signaling

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.1658-1658

2023

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Abstract 3730: A quick and cost effective 12-cell line panel assay to predict drug activity in human tumor xenograft models

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.3730-3730

2014

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Brain Abscess in a Rhesus Macaque (Macaca mulatta) with a Cephalic Implant

Comparative medicine, 2013-08, Vol.63 (4), p.367-372

2013

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Phosphodiesterase 10A (PDE10A) as a novel target to suppress β-catenin and RAS signaling in epithelial ovarian cancer

Abstract 326: Discovery and in vitro and in vivo characterization of a novel, small-molecule Ras inhibitor class

Abstract 1213: PDE10A as a novel target to suppress Wnt/β-catenin signaling and other oncogenic pathways in ovarian cancer

Abstract 2731: A novel PDE10/beta-catenin inhibitor, MCI-048, suppresses lung tumorigenesis to block metastasis

Abstract 2707: A novel RAS inhibitor, MCI-062, inhibits colon tumor growth in vivo and activates antitumor immunity

Abstract 345: Novel RAS inhibitor, MCI-062, potently and selectively inhibits the growth of KRAS mutant pancreatic tumor cells by blocking GTP loading of RAS

Abstract 5166: Sensitivity of melanoma cells to a novel class of Ras inhibitors

Abstract 1937: Inhibition of a novel cancer target, PDE10, suppresses Wnt/β-catenin signaling and colon tumorigenesis: Benefits from combining with ornithine decarboxylase inhibitors

Suppression of Colon Tumorigenesis in Mutant Apc Mice by a Novel PDE10 Inhibitor that Reduces Oncogenic β-Catenin

Abstract 4822: Targeting RAS and downstream signaling in high-grade serous ovarian carcinoma with novel RAS inhibitors

Abstract 3864: A novel PDE10/β-catenin pathway inhibitor, MCI-030, for the treatment of colorectal cancer

Abstract B54: Targeting constitutively active RAS signaling in high-grade serous ovarian carcinoma (HGSOC) with ADT-006, a novel small molecule that blocks RAS-effector interactions

Genome sequence of the dissimilatory metal ion-reducing bacterium Shewanella oneidensis

Abstract 5174: Phosphodiesterase 10A inhibition as a novel approach to suppress β-catenin signaling in ovarian cancer cells

Abstract 4972: Novel Ras inhibitor DC070-547 potently and selectively blocks Ras-RBD binding, EGFR binding to Ras signaling complex, EGFR activation of Ras signaling, and growth of Ras-driven lung tumor cells

Abstract 5159: Characterization of a novel class of RAS inhibitory compounds with potent anti-tumor activity

Phosphodiesterase 10A (PDE10A) as a novel target to suppress [beta]-catenin and RAS signaling in epithelial ovarian cancer

Abstract 1633: ADT-030, a novel dual-acting RAS and β-catenin inhibitor with robust antitumor activity

Abstract B23: DC070-547, a novel Ras inhibitor potently and selectivity inhibits colon tumor growth in vitro and in vivo

Abstract 1238: A novel Ras inhibitor potently and selectively suppresses lung tumor cell growth by blocking Ras-Raf binding

Abstract 1140: Characterization of a novel PDE10 inhibitor in lung tumor cells and an orthotopic mouse model of lung cancer

Abstract LB322: Antitumor activity of 1st-in-class pan-RAS inhibitor ADT-1004 in mouse models of pancreatic ductal adenocarcinoma

Abstract 1658: ADT-007 binds RAS and inhibits RAS signaling

Abstract 3730: A quick and cost effective 12-cell line panel assay to predict drug activity in human tumor xenograft models

Brain Abscess in a Rhesus Macaque (Macaca mulatta) with a Cephalic Implant

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