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The application of targeted protein degradation technologies to G protein‐coupled receptors

British journal of pharmacology, 2024-07, Vol.181 (14), p.2351-2358

2024

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Restraining the power of Proteolysis Targeting Chimeras in the cage: A necessary and important refinement for therapeutic safety

Journal of cellular physiology, 2024-05, Vol.239 (5), p.e31255-n/a

2024

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Conditional Degrons for Controlling Protein Expression at the Protein Level

Annual review of genetics, 2017-11, Vol.51 (1), p.83-102

2017

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Bioinspired PROTAC-induced macrophage fate determination alleviates atherosclerosis

Acta pharmacologica Sinica, 2023-10, Vol.44 (10), p.1962-1976

2023

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Targeted Protein Degradation (TPD) for Immunotherapy: Understanding Proteolysis Targeting Chimera-Driven Ubiquitin-Proteasome Interactions

Bioconjugate chemistry, 2024-08, Vol.35 (8), p.1089-1115

2024

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Expression and function of epithelial cell adhesion molecule EpCAM: where are we after 40 years?

Cancer and metastasis reviews, 2020-09, Vol.39 (3), p.969-987

2020

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New-generation advanced PROTACs as potential therapeutic agents in cancer therapy

Molecular cancer, 2024-05, Vol.23 (1), p.110-41, Article 110

2024

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Proteolysis-targeting chimera (PROTAC) for targeted protein degradation and cancer therapy

Journal of hematology and oncology, 2020-05, Vol.13 (1), p.50-14, Article 50

2020

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Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity

Nature communications, 2020-04, Vol.11 (1), p.1996-14, Article 1996

2020

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Redefining the Scope of Targeted Protein Degradation: Translational Opportunities in Hijacking the Autophagy–Lysosome Pathway

Biochemistry (Easton), 2023-02, Vol.62 (3), p.580-587

2023

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Discovery of ARD-2051 as a Potent and Orally Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer

Journal of medicinal chemistry, 2023-07, Vol.66 (13), p.8822-8843

2023

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Cellular quality control by the ubiquitin-proteasome system and autophagy

Science (American Association for the Advancement of Science), 2019-11, Vol.366 (6467), p.818-822

2019

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EZH2 PROTACs target EZH2- and FOXM1-associated oncogenic nodes, suppressing breast cancer cell growth

Oncogene, 2024-08, Vol.43 (36), p.2722-2736

2024

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PROTACs in Ovarian Cancer: Current Advancements and Future Perspectives

International journal of molecular sciences, 2024-05, Vol.25 (10), p.5067

2024

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Harnessing PROTACs to combat H5N1 influenza: A new frontier in viral destruction

Journal of medical virology, 2024-09, Vol.96 (9), p.e29926-n/a

2024

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Curcumin and Resveratrol Improve Muscle Function and Structure through Attenuation of Proteolytic Markers in Experimental Cancer-Induced Cachexia

Molecules (Basel, Switzerland), 2021-08, Vol.26 (16), p.4904

2021

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Chaperone-mediated autophagy and endosomal microautophagy: Joint by a chaperone

The Journal of biological chemistry, 2018-04, Vol.293 (15), p.5414-5424

2018

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Physicochemical Property Determinants of Oral Absorption for PROTAC Protein Degraders

Journal of medicinal chemistry, 2023-06, Vol.66 (12), p.8281-8287

2023

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A dual-action peptide-containing hydrogel targets wound infection and inflammation

Science translational medicine, 2020-01, Vol.12 (524)

2020

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Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood–Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2

Journal of the American Chemical Society, 2022-09, Vol.144 (37), p.16930-16952

2022

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Discovery of Potent and Selective WDR5 Proteolysis Targeting Chimeras as Potential Therapeutics for Pancreatic Cancer

Journal of medicinal chemistry, 2023-12, Vol.66 (23), p.16168-16186

2023

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Mutant-selective degradation by BRAF-targeting PROTACs

Nature communications, 2021-02, Vol.12 (1), p.920-11, Article 920

2021

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Identification of Proteolysis Targeting Chimeras (PROTACs) for Lysine Demethylase 5 and Their Neurite Outgrowth-Promoting Activity

Chemical and Pharmaceutical Bulletin, 2024/07/01, Vol.72(7), pp.638-647

2024

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Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-β

Science translational medicine, 2020-01, Vol.12 (525)

2020

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Resistance to the Antibody-Drug Conjugate T-DM1 Is Based in a Reduction in Lysosomal Proteolytic Activity

Cancer research (Chicago, Ill.), 2017-09, Vol.77 (17), p.4639-4651

2017

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The application of targeted protein degradation technologies to G protein‐coupled receptors

Restraining the power of Proteolysis Targeting Chimeras in the cage: A necessary and important refinement for therapeutic safety

Conditional Degrons for Controlling Protein Expression at the Protein Level

Bioinspired PROTAC-induced macrophage fate determination alleviates atherosclerosis

Targeted Protein Degradation (TPD) for Immunotherapy: Understanding Proteolysis Targeting Chimera-Driven Ubiquitin-Proteasome Interactions

Expression and function of epithelial cell adhesion molecule EpCAM: where are we after 40 years?

New-generation advanced PROTACs as potential therapeutic agents in cancer therapy

Proteolysis-targeting chimera (PROTAC) for targeted protein degradation and cancer therapy

Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity

Redefining the Scope of Targeted Protein Degradation: Translational Opportunities in Hijacking the Autophagy–Lysosome Pathway

Discovery of ARD-2051 as a Potent and Orally Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer

Cellular quality control by the ubiquitin-proteasome system and autophagy

EZH2 PROTACs target EZH2- and FOXM1-associated oncogenic nodes, suppressing breast cancer cell growth

PROTACs in Ovarian Cancer: Current Advancements and Future Perspectives

Harnessing PROTACs to combat H5N1 influenza: A new frontier in viral destruction

Curcumin and Resveratrol Improve Muscle Function and Structure through Attenuation of Proteolytic Markers in Experimental Cancer-Induced Cachexia

Chaperone-mediated autophagy and endosomal microautophagy: Joint by a chaperone

Physicochemical Property Determinants of Oral Absorption for PROTAC Protein Degraders

A dual-action peptide-containing hydrogel targets wound infection and inflammation

Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood–Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2

Discovery of Potent and Selective WDR5 Proteolysis Targeting Chimeras as Potential Therapeutics for Pancreatic Cancer

Mutant-selective degradation by BRAF-targeting PROTACs

Identification of Proteolysis Targeting Chimeras (PROTACs) for Lysine Demethylase 5 and Their Neurite Outgrowth-Promoting Activity

Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-β

Resistance to the Antibody-Drug Conjugate T-DM1 Is Based in a Reduction in Lysosomal Proteolytic Activity

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