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Targeting PI3K in cancer: mechanisms and advances in clinical trials

Molecular cancer, 2019-02, Vol.18 (1), p.26-26, Article 26

2019

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Circular RNA circBFAR promotes the progression of pancreatic ductal adenocarcinoma via the miR-34b-5p/MET/Akt axis

Molecular cancer, 2020-05, Vol.19 (1), p.83-83, Article 83

2020

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Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation

Nature medicine, 2017-09, Vol.23 (9), p.1055-1062

2017

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Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers

Nature medicine, 2015-03, Vol.21 (3), p.231-238

2015

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PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis

Nature medicine, 2014-11, Vol.20 (11), p.1270-1278

2014

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Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1

Nature medicine, 2012-03, Vol.18 (3), p.388-395

2012

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Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery

Nature reviews. Drug discovery, 2005-12, Vol.4 (12), p.988-1004

2005

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AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy

Oncogene, 2012-04, Vol.31 (15), p.1949-1962

2012

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ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway

Molecular cancer, 2017-04, Vol.16 (1), p.79-79, Article 79

2017

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CircPLEKHM3 acts as a tumor suppressor through regulation of the miR-9/BRCA1/DNAJB6/KLF4/AKT1 axis in ovarian cancer

Molecular cancer, 2019-10, Vol.18 (1), p.144-144, Article 144

2019

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Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

Nature medicine, 2007-10, Vol.13 (10), p.1203-1210

2007

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A gene expression signature of RAS pathway dependence predicts response to PI3K and RAS pathway inhibitors and expands the population of RAS pathway activated tumors

BMC genomics, 2010-06, Vol.3 (1), p.26-26, Article 26

2010

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Activation of β-catenin and Akt pathways by Twist are critical for the maintenance of EMT associated cancer stem cell-like characters

BMC cancer, 2011-02, Vol.11 (1), p.49-49, Article 49

2011

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PTEN/PTENP1: 'Regulating the regulator of RTK-dependent PI3K/Akt signalling', new targets for cancer therapy

Molecular cancer, 2018-02, Vol.17 (1), p.37-37, Article 37

2018

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PTEN opposes negative selection and enables oncogenic transformation of pre-B cells

Nature medicine, 2016-04, Vol.22 (4), p.379-387

2016

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Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma

Nature medicine, 2007-01, Vol.13 (1), p.84-88

2007

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Aryl hydrocarbon receptor/cytochrome P450 1A1 pathway mediates breast cancer stem cells expansion through PTEN inhibition and β-Catenin and Akt activation

Molecular cancer, 2017-01, Vol.16 (1), p.14, Article 14

2017

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Receptor tyrosine kinases (RTKs) in breast cancer: signaling, therapeutic implications and challenges

Molecular cancer, 2018-02, Vol.17 (1), p.34-34, Article 34

2018

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Kaempferol induces ROS-dependent apoptosis in pancreatic cancer cells via TGM2-mediated Akt/mTOR signaling

BMC cancer, 2021-04, Vol.21 (1), p.396-11, Article 396

2021

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METTL3-mediated maturation of miR-126-5p promotes ovarian cancer progression via PTEN-mediated PI3K/Akt/mTOR pathway

Cancer gene therapy, 2021-04, Vol.28 (3-4), p.335-349

2021

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LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes

Nature medicine, 2015-03, Vol.21 (3), p.239-247

2015

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Targeting β1-integrin signaling enhances regeneration in aged and dystrophic muscle in mice

Nature medicine, 2016-08, Vol.22 (8), p.889-896

2016

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Pim-1 regulates cardiomyocyte survival downstream of Akt

Nature medicine, 2007-12, Vol.13 (12), p.1467-1475

2007

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Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

Nature medicine, 2012-07, Vol.18 (7), p.1095-1101

2012

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Targeting PI3K in cancer: mechanisms and advances in clinical trials

Circular RNA circBFAR promotes the progression of pancreatic ductal adenocarcinoma via the miR-34b-5p/MET/Akt axis

Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation

Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers

PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis

Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1

Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy

ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway

CircPLEKHM3 acts as a tumor suppressor through regulation of the miR-9/BRCA1/DNAJB6/KLF4/AKT1 axis in ovarian cancer

Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

A gene expression signature of RAS pathway dependence predicts response to PI3K and RAS pathway inhibitors and expands the population of RAS pathway activated tumors

Activation of β-catenin and Akt pathways by Twist are critical for the maintenance of EMT associated cancer stem cell-like characters

PTEN/PTENP1: 'Regulating the regulator of RTK-dependent PI3K/Akt signalling', new targets for cancer therapy

PTEN opposes negative selection and enables oncogenic transformation of pre-B cells

Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA

Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma

Aryl hydrocarbon receptor/cytochrome P450 1A1 pathway mediates breast cancer stem cells expansion through PTEN inhibition and β-Catenin and Akt activation

Receptor tyrosine kinases (RTKs) in breast cancer: signaling, therapeutic implications and challenges

Kaempferol induces ROS-dependent apoptosis in pancreatic cancer cells via TGM2-mediated Akt/mTOR signaling

METTL3-mediated maturation of miR-126-5p promotes ovarian cancer progression via PTEN-mediated PI3K/Akt/mTOR pathway

LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes

Targeting β1-integrin signaling enhances regeneration in aged and dystrophic muscle in mice

Pim-1 regulates cardiomyocyte survival downstream of Akt

Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

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