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Accessing Drug Metabolites via Transition-Metal Catalyzed C−H Oxidation: The Liver as Synthetic Inspiration

Angewandte Chemie International Edition, 2016-11, Vol.55 (46), p.14218-14238

International ed. in English, 2016

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Quaternary Charge-Transfer Complex Enables Photoenzymatic Intermolecular Hydroalkylation of Olefins

Journal of the American Chemical Society, 2021-01, Vol.143 (1), p.97-102

2021

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Intermolecular Crossed [2 + 2] Cycloaddition Promoted by Visible-Light Triplet Photosensitization: Expedient Access to Polysubstituted 2‑Oxaspiro[3.3]heptanes

Journal of the American Chemical Society, 2021-03, Vol.143 (10), p.4055-4063

2021

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Synthetic strategy: natural products on demand

Nature chemistry, 2014-06, Vol.6 (6), p.460

Hamann, Lawrence G

2014

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Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

Nature (London), 2010-05, Vol.465 (7294), p.96-100

2010

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Regioselective Synthesis and Slow-Release Suzuki–Miyaura Cross-Coupling of MIDA Boronate-Functionalized Isoxazoles and Triazoles

Journal of organic chemistry, 2011-12, Vol.76 (24), p.10241-10248

2011

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Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ERα+ Breast Cancer

Journal of medicinal chemistry, 2017-04, Vol.60 (7), p.2790-2818

2017

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Die Erschließung von Wirkstoffmetaboliten durch übergangsmetallkatalysierte C-H-Oxidation: die Leber als Inspiration für die Synthese

Angewandte Chemie, 2016-11, Vol.128 (46), p.14430-14451

2016

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One-Pot Reductive Amination and Suzuki–Miyaura Cross-Coupling of Formyl Aryl and Heteroaryl MIDA Boronates in Array Format

Journal of organic chemistry, 2011-06, Vol.76 (12), p.4930-4940

2011

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One-Pot C–N/C–C Cross-Coupling of Methyliminodiacetic Acid Boronyl Arenes Enabled by Protective Enolization

Organic letters, 2012-11, Vol.14 (21), p.5578-5581

2012

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Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists

Nature (London), 1997-03, Vol.386 (6623), p.407-410

1997

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Optimization of Activity, Selectivity, and Liability Profiles in 5‑Oxopyrrolopyridine DPP4 Inhibitors Leading to Clinical Candidate (Sa)‑2-(3-(Aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo‑5H‑pyrrolo[3,4‑b]pyridin-6(7H)‑yl)‑N,N‑dimethylacetamide (BMS-767778)

Journal of medicinal chemistry, 2013-09, Vol.56 (18), p.7343-7357

2013

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A scalable synthesis of (1R,3S,5R)-2-(tert-butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic acid

Tetrahedron letters, 2013-12, Vol.54 (49), p.6722-6724

2013

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Palladium-Catalyzed Microwave-Assisted Amination of 1-Bromonaphthalenes and 5- and 8-Bromoquinolines

Organic letters, 2003-03, Vol.5 (6), p.897-900

2003

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Natural products on demand

Nature chemistry, 2014, Vol.6 (6), p.460-461

Hamann, Lawrence G.

2014

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Synthesis and Biological Activity of a Novel Series of Nonsteroidal, Peripherally Selective Androgen Receptor Antagonists Derived from 1,2-Dihydropyridono[5,6-g]quinolines

Journal of medicinal chemistry, 1998-02, Vol.41 (4), p.623-639

1998

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An Efficient, Stereospecific Synthesis of the Dimer-Selective Retinoid X Receptor Modulator (2E,4E,6Z)-7-[5,6,7,8- Tetrahydro-5,5,8,8-tetramethyl-2- (n-propyloxy)naphthalen-3-yl]-3- methylocta-2,4,6-trienoic Acid

Journal of organic chemistry, 2000-05, Vol.65 (10), p.3233-3235

Hamann, Lawrence G

2000

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The 2 nd Alpine Winter Conference on Medicinal and Synthetic Chemistry

ChemMedChem, 2021-08, Vol.16 (15), p.2417-2423

2021

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A scalable synthesis of (1R,3S,5R)-2-(tert-butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-car b oxylic acid

Tetrahedron letters, 2013-12, Vol.54 (49), p.6722-6724

2013

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ChemInform Abstract: Accessing Drug Metabolites via Transition‐Metal Catalyzed C—H Oxidation: The Liver as Synthetic Inspiration

ChemInform, 2016-12, Vol.47 (51), p.no-no

2016

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Die Erschließung von Wirkstoffmetaboliten durch übergangsmetallkatalysierte C‐H‐Oxidation: die Leber als Inspiration für die Synthese

Angewandte Chemie, 2016-11, Vol.128 (46), p.14430-14451

2016

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Chirality transmission involving a free-radical-mediated 6-exo cyclization process. Stereocontrolled synthesis of branched-chain 1,4-diols

Journal of the American Chemical Society, 1990-10, Vol.112 (22), p.8175-8177

1990

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Optimization of Activity, Selectivity, and Liability Profiles in 5-Oxopyrrolopyridine DPP4 Inhibitors Leading to Clinical Candidate ( Sa )-2-(3-(Aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5 H -pyrrolo[3,4- b ]pyridin-6(7 H )-yl)- N , N -dimethylacetamide (BMS-767778)

Journal of medicinal chemistry, 2013-09, Vol.56 (18), p.7343-7357

2013

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Accessing Drug Metabolites via Transition-Metal Catalyzed C−H Oxidation: The Liver as Synthetic Inspiration

Quaternary Charge-Transfer Complex Enables Photoenzymatic Intermolecular Hydroalkylation of Olefins

Intermolecular Crossed [2 + 2] Cycloaddition Promoted by Visible-Light Triplet Photosensitization: Expedient Access to Polysubstituted 2‑Oxaspiro[3.3]heptanes

Synthetic strategy: natural products on demand

Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

Regioselective Synthesis and Slow-Release Suzuki–Miyaura Cross-Coupling of MIDA Boronate-Functionalized Isoxazoles and Triazoles

Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ERα+ Breast Cancer

Die Erschließung von Wirkstoffmetaboliten durch übergangsmetallkatalysierte C-H-Oxidation: die Leber als Inspiration für die Synthese

One-Pot Reductive Amination and Suzuki–Miyaura Cross-Coupling of Formyl Aryl and Heteroaryl MIDA Boronates in Array Format

One-Pot C–N/C–C Cross-Coupling of Methyliminodiacetic Acid Boronyl Arenes Enabled by Protective Enolization

Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists

Optimization of Activity, Selectivity, and Liability Profiles in 5‑Oxopyrrolopyridine DPP4 Inhibitors Leading to Clinical Candidate (Sa)‑2-(3-(Aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo‑5H‑pyrrolo[3,4‑b]pyridin-6(7H)‑yl)‑N,N‑dimethylacetamide (BMS-767778)

A scalable synthesis of (1R,3S,5R)-2-(tert-butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic acid

Palladium-Catalyzed Microwave-Assisted Amination of 1-Bromonaphthalenes and 5- and 8-Bromoquinolines

Natural products on demand

Synthesis and Biological Activity of a Novel Series of Nonsteroidal, Peripherally Selective Androgen Receptor Antagonists Derived from 1,2-Dihydropyridono[5,6-g]quinolines

An Efficient, Stereospecific Synthesis of the Dimer-Selective Retinoid X Receptor Modulator (2E,4E,6Z)-7-[5,6,7,8- Tetrahydro-5,5,8,8-tetramethyl-2- (n-propyloxy)naphthalen-3-yl]-3- methylocta-2,4,6-trienoic Acid

The 2 nd Alpine Winter Conference on Medicinal and Synthetic Chemistry

A scalable synthesis of (1R,3S,5R)-2-(tert-butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-car b oxylic acid

ChemInform Abstract: Accessing Drug Metabolites via Transition‐Metal Catalyzed C—H Oxidation: The Liver as Synthetic Inspiration

Die Erschließung von Wirkstoffmetaboliten durch übergangsmetallkatalysierte C‐H‐Oxidation: die Leber als Inspiration für die Synthese

Chirality transmission involving a free-radical-mediated 6-exo cyclization process. Stereocontrolled synthesis of branched-chain 1,4-diols

Erratum: Corrigendum: SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice

Erratum: Corrigendum: SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice

Optimization of Activity, Selectivity, and Liability Profiles in 5-Oxopyrrolopyridine DPP4 Inhibitors Leading to Clinical Candidate ( Sa )-2-(3-(Aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5 H -pyrrolo[3,4- b ]pyridin-6(7 H )-yl)- N , N -dimethylacetamide (BMS-767778)

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