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PI3Kγ is a molecular switch that controls immune suppression

Nature (London), 2016-11, Vol.539 (7629), p.437-442

2016

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Palmatine Derivatives as Potential Antiplatelet Aggregation Agents via Protein Kinase G/Vasodilator-Stimulated Phosphoprotein and Phosphatidylinositol 3‑Kinase/Akt Phosphorylation

Journal of medicinal chemistry, 2022-05, Vol.65 (10), p.7399-7413

2022

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A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

Nature (London), 2015-04, Vol.520 (7549), p.683-687

2015

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Quercetin inhibited epithelial mesenchymal transition in diabetic rats, high-glucose-cultured lens, and SRA01/04 cells through transforming growth factor-β2/phosphoinositide 3-kinase/Akt pathway

Molecular and cellular endocrinology, 2017-09, Vol.452, p.44-56

2017

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Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice

Gastroenterology (New York, N.Y. 1943), 2015-12, Vol.149 (7), p.1884-1895.e4

2015

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Structural characterization and immunomodulatory activity of a water-soluble polysaccharide from Ganoderma leucocontextum fruiting bodies

Carbohydrate polymers, 2020-12, Vol.249, p.116874-116874, Article 116874

2020

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Maximising the potential of AKT inhibitors as anti-cancer treatments

Pharmacology & therapeutics (Oxford), 2017-04, Vol.172, p.101-115

2017

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Absence of signaling into CD4⁺ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3⁺ regulatory T cells

Nature immunology, 2013-02, Vol.14 (2), p.162

2013

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Report of a Chinese Cohort with Activated Phosphoinositide 3-Kinase δ Syndrome

Journal of clinical immunology, 2018-11, Vol.38 (8), p.854-863

2018

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TLR9 and beclin 1 crosstalk regulates muscle AMPK activation in exercise

Nature (London), 2020-02, Vol.578 (7796), p.605-609

2020

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Structure of the Human TELO2-TTI1-TTI2 Complex

Journal of molecular biology, 2022-01, Vol.434 (2), p.167370-167370, Article 167370

2022

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PI3Kβ controls immune evasion in PTEN-deficient breast tumours

Nature (London), 2023-05, Vol.617 (7959), p.139-146

2023

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Involvement of α7nAChR in the Protective Effects of Genistein Against β-Amyloid-Induced Oxidative Stress in Neurons via a PI3K/Akt/Nrf2 Pathway-Related Mechanism

Cellular and molecular neurobiology, 2021-03, Vol.41 (2), p.377-393

2021

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The neurotrophin family of neurotrophic factors: an overview

Methods in molecular biology (Clifton, N.J.), 2012, Vol.846, p.1

Skaper, Stephen D

2012

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Cannabidiol induces systemic analgesia through activation of the PI3Kγ/nNOS/NO/KATP signaling pathway in neuropathic mice. A KATP channel S-nitrosylation-dependent mechanism

Nitric oxide, 2024-05, Vol.146, p.1-9

2024

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Aggressive migration in acidic pH of a glioblastoma cancer stem cell line in vitro is independent of ASIC and K Ca 3.1 ion channels, but involves phosphoinositide 3-kinase

Pflügers Archiv, 2023-03, Vol.475 (3), p.405

2023

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Pinocembrin inhibits lipopolysaccharide-induced inflammatory mediators production in BV2 microglial cells through suppression of PI3K/Akt/NF-κB pathway

European journal of pharmacology, 2015-08, Vol.761, p.211-216

2015

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Protective effects of ginsenoside Rg2 against memory impairment and neuronal death induced by Aβ25-35 in rats

Journal of ethnopharmacology, 2021-02, Vol.266, p.113466, Article 113466

2021

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Small integral membrane protein 10 like 1 downregulation enhances differentiation of adipose progenitor cells

Biochemical and biophysical research communications, 2022-05, Vol.604, p.57-62

2022

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Atropisomerism and Conformational Equilibria: Impact on PI3Kδ Inhibition of 2‑((6-Amino‑9H‑purin-9-yl)methyl)-5-methyl-3‑(o‑tolyl)quinazolin-4(3H)‑one (IC87114) and Its Conformationally Restricted Analogs

Journal of medicinal chemistry, 2017-05, Vol.60 (10), p.4304-4315

2017

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Regulation of optimized new Shengmai powder on cardiomyocyte apoptosis and ferroptosis in ischemic heart failure rats: The mediating role of phosphatidylinositol-3-kinase/protein kinase B/tumor protein 53 signaling pathway

Journal of ethnopharmacology, 2024-08, Vol.330, p.118264-118264, Article 118264

2024

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Effects of Quercetin on Autophagy and Phosphatidylinositol 3-kinase/Protein Kinase B/Mammalian Target of Rapamycin Signaling Pathway in Human Prostate Cancer PC-3 Cells

Zhōngguó yīxué kēxuéyuàn xuébào, 2020-10, Vol.42 (5), p.578

2020

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LncRNA SNHG11 promotes malignant progression of colorectal cancer cells through the PI3K/Akt/mTOR signaling pathway

Zhong hua yi xue za zhi, 2024-03, Vol.104 (10), p.758-765

2024

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PI3Kα inhibitor GNE-493 triggers antitumor immunity in murine lung cancer by inducing immunogenic cell death and activating T cells

International immunopharmacology, 2024-03, Vol.130, p.111747-111747, Article 111747

2024

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Tetrahedral Framework Nucleic Acids Ameliorate Insulin Resistance in Type 2 Diabetes Mellitus via the PI3K/Akt Pathway

ACS applied materials & interfaces, 2021-09, Vol.13 (34), p.40354-40364

2021

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PI3Kγ is a molecular switch that controls immune suppression

Palmatine Derivatives as Potential Antiplatelet Aggregation Agents via Protein Kinase G/Vasodilator-Stimulated Phosphoprotein and Phosphatidylinositol 3‑Kinase/Akt Phosphorylation

A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

Quercetin inhibited epithelial mesenchymal transition in diabetic rats, high-glucose-cultured lens, and SRA01/04 cells through transforming growth factor-β2/phosphoinositide 3-kinase/Akt pathway

Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice

Structural characterization and immunomodulatory activity of a water-soluble polysaccharide from Ganoderma leucocontextum fruiting bodies

Maximising the potential of AKT inhibitors as anti-cancer treatments

Absence of signaling into CD4⁺ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3⁺ regulatory T cells

Report of a Chinese Cohort with Activated Phosphoinositide 3-Kinase δ Syndrome

TLR9 and beclin 1 crosstalk regulates muscle AMPK activation in exercise

Structure of the Human TELO2-TTI1-TTI2 Complex

PI3Kβ controls immune evasion in PTEN-deficient breast tumours

Involvement of α7nAChR in the Protective Effects of Genistein Against β-Amyloid-Induced Oxidative Stress in Neurons via a PI3K/Akt/Nrf2 Pathway-Related Mechanism

The neurotrophin family of neurotrophic factors: an overview

Cannabidiol induces systemic analgesia through activation of the PI3Kγ/nNOS/NO/KATP signaling pathway in neuropathic mice. A KATP channel S-nitrosylation-dependent mechanism

Aggressive migration in acidic pH of a glioblastoma cancer stem cell line in vitro is independent of ASIC and K Ca 3.1 ion channels, but involves phosphoinositide 3-kinase

Pinocembrin inhibits lipopolysaccharide-induced inflammatory mediators production in BV2 microglial cells through suppression of PI3K/Akt/NF-κB pathway

Protective effects of ginsenoside Rg2 against memory impairment and neuronal death induced by Aβ25-35 in rats

Small integral membrane protein 10 like 1 downregulation enhances differentiation of adipose progenitor cells

Atropisomerism and Conformational Equilibria: Impact on PI3Kδ Inhibition of 2‑((6-Amino‑9H‑purin-9-yl)methyl)-5-methyl-3‑(o‑tolyl)quinazolin-4(3H)‑one (IC87114) and Its Conformationally Restricted Analogs

Regulation of optimized new Shengmai powder on cardiomyocyte apoptosis and ferroptosis in ischemic heart failure rats: The mediating role of phosphatidylinositol-3-kinase/protein kinase B/tumor protein 53 signaling pathway

Effects of Quercetin on Autophagy and Phosphatidylinositol 3-kinase/Protein Kinase B/Mammalian Target of Rapamycin Signaling Pathway in Human Prostate Cancer PC-3 Cells

LncRNA SNHG11 promotes malignant progression of colorectal cancer cells through the PI3K/Akt/mTOR signaling pathway

PI3Kα inhibitor GNE-493 triggers antitumor immunity in murine lung cancer by inducing immunogenic cell death and activating T cells

Tetrahedral Framework Nucleic Acids Ameliorate Insulin Resistance in Type 2 Diabetes Mellitus via the PI3K/Akt Pathway

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