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Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

The Journal of clinical investigation, 2011-09, Vol.121 (9), p.3375-3383

2011

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Interleukin-6: From basic biology to selective blockade of pro-inflammatory activities

Seminars in immunology, 2014-02, Vol.26 (1), p.2-12

2014

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The pro- and anti-inflammatory properties of the cytokine interleukin-6

Biochimica et biophysica acta, 2011-05, Vol.1813 (5), p.878-888

2011

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IL-6 in the infarcted heart is preferentially formed by fibroblasts and modulated by purinergic signaling

The Journal of clinical investigation, 2023-06, Vol.133 (11), p.1-14

2023

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Trans-signaling is a dominant mechanism for the pathogenic actions of interleukin-6 in the brain

The Journal of neuroscience, 2014-02, Vol.34 (7), p.2503-2513

2014

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Plasticity and cross-talk of Interleukin 6-type cytokines

Cytokine & growth factor reviews, 2012-06, Vol.23 (3), p.85-97

2012

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ADAM17: a molecular switch to control inflammation and tissue regeneration

Trends in immunology, 2011-08, Vol.32 (8), p.380-387

2011

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CD73‐derived adenosine and tenascin‐C control cytokine production by epicardium‐derived cells formed after myocardial infarction

The FASEB journal, 2017-07, Vol.31 (7), p.3040-3053

2017

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IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

Cancer cell, 2009-02, Vol.15 (2), p.103-113

2009

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A widespread sequence-specific mRNA decay pathway mediated by hnRNPs A1 and A2/B1

Genes & development, 2016-05, Vol.30 (9), p.1070-1085

2016

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The soluble Interleukin 6 receptor: Generation and role in inflammation and cancer

European journal of cell biology, 2011-06, Vol.90 (6), p.484-494

2011

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Therapeutic Targeting of IL-6 Trans Signaling Counteracts STAT3 Control of Experimental Inflammatory Arthritis

The Journal of immunology (1950), 2009-01, Vol.182 (1), p.613-622

2009

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IL-12 and IL-23—Close Relatives with Structural Homologies but Distinct Immunological Functions

Cells (Basel, Switzerland), 2020-09, Vol.9 (10), p.2184

2020

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Essential Roles of IL-6 Trans-Signaling in Colonic Epithelial Cells, Induced by the IL-6/Soluble-IL-6 Receptor Derived from Lamina Propria Macrophages, on the Development of Colitis-Associated Premalignant Cancer in a Murine Model

The Journal of immunology (1950), 2010-02, Vol.184 (3), p.1543-1551

2010

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Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer

Journal of leukocyte biology, 2006-08, Vol.80 (2), p.227-236

2006

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Soluble gp130 prevents interleukin-6 and interleukin-11 cluster signaling but not intracellular autocrine responses

Science signaling, 2018-10, Vol.11 (550)

2018

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IL‐6 Trans‐signaling Controls Liver Regeneration After Partial Hepatectomy

Hepatology (Baltimore, Md.), 2019-12, Vol.70 (6), p.2075-2091

2019

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Exploring the landscape of synthetic IL-6-type cytokines

The FEBS journal, 2024-05, Vol.291 (10), p.2030-2050

2024

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Interleukin 17 drives vascular inflammation, endothelial dysfunction, and arterial hypertension in psoriasis-like skin disease

Arteriosclerosis, thrombosis, and vascular biology, 2014-12, Vol.34 (12), p.2658-2668

2014

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The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases

Biochimica et biophysica acta, 2014-09, Vol.1842 (9), p.1485-1494

2014

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Transgenic blockade of interleukin 6 transsignaling abrogates inflammation

Blood, 2008-02, Vol.111 (3), p.1021-1028

2008

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Species Specificity of ADAM10 and ADAM17 Proteins in Interleukin-6 (IL-6) Trans-signaling and Novel Role of ADAM10 in Inducible IL-6 Receptor Shedding

The Journal of biological chemistry, 2011-04, Vol.286 (17), p.14804-14811

2011

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An Interleukin-6 Receptor-dependent Molecular Switch Mediates Signal Transduction of the IL-27 Cytokine Subunit p28 (IL-30) via a gp130 Protein Receptor Homodimer

The Journal of biological chemistry, 2013-02, Vol.288 (6), p.4346-4354

2013

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Inflammation-Induced IL-6 Functions as a Natural Brake on Macrophages and Limits GN

Journal of the American Society of Nephrology, 2015-07, Vol.26 (7), p.1597-1607

2015

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Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice

The Journal of experimental medicine, 2010-08, Vol.207 (8), p.1617-1624

2010

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Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

Interleukin-6: From basic biology to selective blockade of pro-inflammatory activities

The pro- and anti-inflammatory properties of the cytokine interleukin-6

IL-6 in the infarcted heart is preferentially formed by fibroblasts and modulated by purinergic signaling

Trans-signaling is a dominant mechanism for the pathogenic actions of interleukin-6 in the brain

Plasticity and cross-talk of Interleukin 6-type cytokines

ADAM17: a molecular switch to control inflammation and tissue regeneration

CD73‐derived adenosine and tenascin‐C control cytokine production by epicardium‐derived cells formed after myocardial infarction

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

A widespread sequence-specific mRNA decay pathway mediated by hnRNPs A1 and A2/B1

The soluble Interleukin 6 receptor: Generation and role in inflammation and cancer

Therapeutic Targeting of IL-6 Trans Signaling Counteracts STAT3 Control of Experimental Inflammatory Arthritis

IL-12 and IL-23—Close Relatives with Structural Homologies but Distinct Immunological Functions

Essential Roles of IL-6 Trans-Signaling in Colonic Epithelial Cells, Induced by the IL-6/Soluble-IL-6 Receptor Derived from Lamina Propria Macrophages, on the Development of Colitis-Associated Premalignant Cancer in a Murine Model

Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer

Soluble gp130 prevents interleukin-6 and interleukin-11 cluster signaling but not intracellular autocrine responses

IL‐6 Trans‐signaling Controls Liver Regeneration After Partial Hepatectomy

Exploring the landscape of synthetic IL-6-type cytokines

Interleukin 17 drives vascular inflammation, endothelial dysfunction, and arterial hypertension in psoriasis-like skin disease

The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases

Transgenic blockade of interleukin 6 transsignaling abrogates inflammation

Species Specificity of ADAM10 and ADAM17 Proteins in Interleukin-6 (IL-6) Trans-signaling and Novel Role of ADAM10 in Inducible IL-6 Receptor Shedding

An Interleukin-6 Receptor-dependent Molecular Switch Mediates Signal Transduction of the IL-27 Cytokine Subunit p28 (IL-30) via a gp130 Protein Receptor Homodimer

Inflammation-Induced IL-6 Functions as a Natural Brake on Macrophages and Limits GN

Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice

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