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Autosomal dominant inheritance of a predisposition to thoracic aortic aneurysms and dissections and intracranial saccular aneurysms

American journal of medical genetics. Part A, 2011-09, Vol.155A (9), p.2125-2130

2011

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Mutations in smooth muscle α-actin ( ACTA2 ) lead to thoracic aortic aneurysms and dissections

Nature genetics, 2007-12, Vol.39 (12), p.1488-1493

2007

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Familial aggregation of both aortic and cerebral aneurysms : Evidence for a common genetic basis in a subset of families

Neurosurgery, 2005-04, Vol.56 (4), p.655-661

2005

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DOR activation inhibits anoxic/ischemic Na+ influx through Na+ channels via PKC mechanisms in the cortex

Experimental neurology, 2012-08, Vol.236 (2), p.228-239

2012

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Visual detection of AMP and real-time monitoring of cyclic nucleotide phosphodiesterase (PDE) activity in neutral aqueous solution. Chemosensor-coupled assay of PDE and PDE inhibitors

Bioorganic & medicinal chemistry letters, 2003-03, Vol.13 (6), p.1079-1082

2003

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Syntheses and Kinetic Evaluation of Racemic and Optically Active 2-Benzyl-2-methyl-3,4-epoxybutanoic Acids as Irreversible Inactivators for Carboxypeptidase A

Bioorganic & medicinal chemistry, 2002-04, Vol.10 (4), p.913-922

2002

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Molecular probe for selective detection of thiols in water of neutral pH

Bioorganic & medicinal chemistry letters, 2003-08, Vol.13 (15), p.2543-2546

2003

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Fluorometric Assay Protocol for Protease-Catalyzed Transesterification Reactions in Organic Solvents

Journal of organic chemistry, 2004-04, Vol.69 (8), p.2853-2855

2004

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A metal complex that binds α-amino acids with high and predictable stereospecificity

Nature (London), 1999-09, Vol.401 (6750), p.254-257

1999

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Subacute toxicities and toxicokinetics of DA-8159, a new phosphodiesterase type V inhibitor, after single and 4-Week repeated oral administration in rats

Biopharmaceutics & drug disposition, 2003-12, Vol.24 (9), p.409-418

2003

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Cysteine Derivatives as Inhibitors for Carboxypeptidase A: Synthesis and Structure−Activity Relationships

Journal of medicinal chemistry, 2002-02, Vol.45 (4), p.911-918

2002

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Prevention of apoptotic but not necrotic cell death following neuronal injury by neurotrophins signaling through the tyrosine kinase receptor

Journal of neurosurgery, 2004-01, Vol.100 (1), p.79

2004

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Sulfamide-Based Inhibitors for Carboxypeptidase A. Novel Type Transition State Analogue Inhibitors for Zinc Proteases

Journal of medicinal chemistry, 2002-11, Vol.45 (24), p.5295-5302

2002

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Effect of zinc ion on the inhibition of carboxypeptidase A by imidazole-bearing substrate analogues

Bioorganic & medicinal chemistry letters, 2001-06, Vol.11 (11), p.1425-1427

2001

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Synthesis and evaluation of α,α-disubstituted-3-mercaptopropanoic acids as inhibitors for carboxypeptidase A and implications with respect to enzyme inhibitor design

Bioorganic & medicinal chemistry, 2003-11, Vol.11 (22), p.4685-4691

2003

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The x-ray crystallographic study of covalently modified carboxypeptidase A by 2-benzyl-3,4-epoxybutanoic acid, a pseudomechanism-based inactivator

Journal of the American Chemical Society, 1992-03, Vol.114 (6), p.2281-2282

1992

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Sulfamide derivatives as transition state analogue inhibitors for carboxypeptidase A

Bioorganic & medicinal chemistry, 2004-05, Vol.12 (9), p.2349-2356

2004

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Mechanism-based inhibition of zinc proteases

Current medicinal chemistry, 2001-07, Vol.8 (8), p.959

2001

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Reversed hydroxamate-Bearing thermolysin inhibitors mimic a high-energy intermediate along the enzyme-Catalyzed proteolytic reaction pathway

Bioorganic & medicinal chemistry letters, 2003-10, Vol.13 (19), p.3161-3166

2003

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Inhibition of α-chymotrypsin with thiol-bearing substrate analogues in the presence of zinc ion

Bioorganic & medicinal chemistry letters, 2004-02, Vol.14 (3), p.701-705

2004

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Treatment with genetically engineered fibroblasts producing NGF or BDNF can accelerate recovery from traumatic spinal cord injury in the adult rat

Neuroreport, 1996-09, Vol.7 (13), p.2221-2230

1996

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Cleavage of β-lactone ring by serine protease. Mechanistic implications

Bioorganic & medicinal chemistry, 2002-08, Vol.10 (8), p.2553-2560

2002

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Insight into the stereochemistry in the inhibition of carboxypeptidase A with N-(hydroxyaminocarbonyl)phenylalanine: binding modes of an enantiomeric pair of the inhibitor to carboxypeptidase A

Bioorganic & medicinal chemistry, 2002-06, Vol.10 (6), p.2015-2022

2002

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N-(Hydroxyaminocarbonyl)phenylalanine : a novel class of inhibitor for carboxypeptidase A

Bioorganic & medicinal chemistry, 2001, Vol.9 (1), p.185-189

2001

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2-Benzyl-3,4-iminobutanoic Acid as Inhibitor of Carboxypeptidase A

Bioorganic & medicinal chemistry letters, 2001-11, Vol.11 (22), p.2967-2970

2001

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Autosomal dominant inheritance of a predisposition to thoracic aortic aneurysms and dissections and intracranial saccular aneurysms

Mutations in smooth muscle α-actin ( ACTA2 ) lead to thoracic aortic aneurysms and dissections

Familial aggregation of both aortic and cerebral aneurysms : Evidence for a common genetic basis in a subset of families

DOR activation inhibits anoxic/ischemic Na+ influx through Na+ channels via PKC mechanisms in the cortex

Visual detection of AMP and real-time monitoring of cyclic nucleotide phosphodiesterase (PDE) activity in neutral aqueous solution. Chemosensor-coupled assay of PDE and PDE inhibitors

Syntheses and Kinetic Evaluation of Racemic and Optically Active 2-Benzyl-2-methyl-3,4-epoxybutanoic Acids as Irreversible Inactivators for Carboxypeptidase A

Molecular probe for selective detection of thiols in water of neutral pH

Fluorometric Assay Protocol for Protease-Catalyzed Transesterification Reactions in Organic Solvents

A metal complex that binds α-amino acids with high and predictable stereospecificity

Subacute toxicities and toxicokinetics of DA-8159, a new phosphodiesterase type V inhibitor, after single and 4-Week repeated oral administration in rats

Cysteine Derivatives as Inhibitors for Carboxypeptidase A: Synthesis and Structure−Activity Relationships

Prevention of apoptotic but not necrotic cell death following neuronal injury by neurotrophins signaling through the tyrosine kinase receptor

Sulfamide-Based Inhibitors for Carboxypeptidase A. Novel Type Transition State Analogue Inhibitors for Zinc Proteases

Effect of zinc ion on the inhibition of carboxypeptidase A by imidazole-bearing substrate analogues

Synthesis and evaluation of α,α-disubstituted-3-mercaptopropanoic acids as inhibitors for carboxypeptidase A and implications with respect to enzyme inhibitor design

The x-ray crystallographic study of covalently modified carboxypeptidase A by 2-benzyl-3,4-epoxybutanoic acid, a pseudomechanism-based inactivator

Sulfamide derivatives as transition state analogue inhibitors for carboxypeptidase A

Mechanism-based inhibition of zinc proteases

Reversed hydroxamate-Bearing thermolysin inhibitors mimic a high-energy intermediate along the enzyme-Catalyzed proteolytic reaction pathway

Inhibition of α-chymotrypsin with thiol-bearing substrate analogues in the presence of zinc ion

Treatment with genetically engineered fibroblasts producing NGF or BDNF can accelerate recovery from traumatic spinal cord injury in the adult rat

Cleavage of β-lactone ring by serine protease. Mechanistic implications

Insight into the stereochemistry in the inhibition of carboxypeptidase A with N-(hydroxyaminocarbonyl)phenylalanine: binding modes of an enantiomeric pair of the inhibitor to carboxypeptidase A

N-(Hydroxyaminocarbonyl)phenylalanine : a novel class of inhibitor for carboxypeptidase A

2-Benzyl-3,4-iminobutanoic Acid as Inhibitor of Carboxypeptidase A

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