UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Datensatz exportieren als...
BibTeX
Efficacy of a rapamycin analog (CCI-779) and IFN-γ in tuberous sclerosis mouse models
Genes chromosomes & cancer, 2005-03, Vol.42 (3), p.213-227
Lee, Laifong
Sudentas, Paul
Donohue, Brian
Asrican, Kirsten
Worku, Aelaf
Walker, Victoria
Sun, Yanping
Schmidt, Karl
Albert, Mitchell S.
El-Hashemite, Nisreen
Lader, Alan S.
Onda, Hiroaki
Zhang, Hongbing
Kwiatkowski, David J.
Dabora, Sandra L.
2005
Details
Autor(en) / Beteiligte
Lee, Laifong
Sudentas, Paul
Donohue, Brian
Asrican, Kirsten
Worku, Aelaf
Walker, Victoria
Sun, Yanping
Schmidt, Karl
Albert, Mitchell S.
El-Hashemite, Nisreen
Lader, Alan S.
Onda, Hiroaki
Zhang, Hongbing
Kwiatkowski, David J.
Dabora, Sandra L.
Titel
Efficacy of a rapamycin analog (CCI-779) and IFN-γ in tuberous sclerosis mouse models
Ist Teil von
Genes chromosomes & cancer, 2005-03, Vol.42 (3), p.213-227
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2005
Link zum Volltext
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
Tuberous sclerosis complex (TSC) is a familial tumor disorder for which there is no effective medical therapy. Disease‐causing mutations in the TSC1 or TSC2 gene lead to increased mammalian target of rapamycin (mTOR) kinase activity in the conserved mTOR signaling pathway, which regulates nutrient uptake, cell growth, and protein translation. The normal function of TSC1 and TSC2 gene products is to form a complex that reduces mTOR kinase activity. Thus, mTOR kinase inhibition may be a useful targeted therapeutic approach. Elevated interferon‐gamma (IFN‐γ) expression is associated with decreased severity of kidney tumors in TSC patients and mouse models; therefore, IFN‐γ also has therapeutic potential. We studied cohorts of Tsc2+/− mice and a novel mouse model of Tsc2‐null tumors in order to evaluate the efficacy of targeted therapy for TSC. We found that treatment with either an mTOR kinase inhibitor (CCI‐779, a rapamycin analog) or with IFN‐γ reduced the severity of TSC‐related disease without significant toxicity. These results constitute definitive preclinical data that justify proceeding with clinical trials using these agents in selected patients with TSC and related disorders. © 2004 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1045-2257
eISSN: 1098-2264
DOI: 10.1002/gcc.20118
Titel-ID: cdi_wiley_primary_10_1002_gcc_20118_GCC20118
Format
–
Schlagworte
Animals
,
Cystadenoma - metabolism
,
Cystadenoma - pathology
,
Cystadenoma - prevention & control
,
Disease Models, Animal
,
Drug Therapy, Combination
,
Hemangioma - metabolism
,
Hemangioma - pathology
,
Hemangioma - prevention & control
,
Interferon-gamma - therapeutic use
,
Kidney Neoplasms - metabolism
,
Kidney Neoplasms - pathology
,
Kidney Neoplasms - prevention & control
,
Liver Neoplasms, Experimental - metabolism
,
Liver Neoplasms, Experimental - pathology
,
Liver Neoplasms, Experimental - prevention & control
,
Mice
,
Mice, Knockout
,
Mice, Nude
,
Phosphorylation
,
Protein Kinases - metabolism
,
Repressor Proteins - genetics
,
Repressor Proteins - physiology
,
Ribosomal Protein S6 Kinases - metabolism
,
Signal Transduction
,
Sirolimus - analogs & derivatives
,
Sirolimus - therapeutic use
,
TOR Serine-Threonine Kinases
,
Tuberous Sclerosis - drug therapy
,
Tuberous Sclerosis - metabolism
,
Tuberous Sclerosis - pathology
,
Tumor Suppressor Proteins - genetics
,
Tumor Suppressor Proteins - physiology
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX