Details

Autor(en) / Beteiligte

• Kasprzak, Kazimierz S
• Salnikow, Konstantin
• Sigel, Roland K. O
• Sigel, Helmut
• Sigel, Astrid

Titel

Nickel Toxicity and Carcinogenesis

Ist Teil von

• Nickel and Its Surprising Impact in Nature, 2007, p.619-660

Ort / Verlag

Chichester, UK: John Wiley & Sons, Ltd

Erscheinungsjahr

2007

Link zum Volltext

Quelle

Wiley-Blackwell Online Books - All Titles (includes Withdrawn titles)

Beschreibungen/Notizen

• Nickel has the potential to produce a variety of pathologic effects in humans. Since it is widely used in modern industries, the exposures and associated health problems are predominantly occupational, but contact with domestic or personal products containing nickel, e.g., jewelry, may produce adverse health reactions, too. The occupational inhalatory exposures to nickel‐containing dusts and fumes may result in asthma, lung fibrosis, and cancer of the nose and lung, while skin exposures, either occupational or incidental, may cause inflammatory response. Nickel is one of the most potent human allergens. Our knowledge on the molecular mechanisms of nickel toxicity and carcinogenicity is sketchy. These mechanisms are likely to involve binding of nickel cation to tissue and cellular components, detrimental to their structure and function, and disruption of the homeostasis of essential metals. At least a part of nickel‐induced toxic and carcinogenic effects is mechanistically associated with generation of reactive oxygen species and inhibition of DNA repair. This chapter describes the symptoms of acute and chronic intoxication with various nickel derivatives in humans and animals, including cancer, and discusses possible underlying mechanisms at the organismal, cellular, and molecular levels.