Details

Autor(en) / Beteiligte

• Itkin, M.
• Heinig, U.
• Tzfadia, O.
• Bhide, A. J.
• Shinde, B.
• Cardenas, P. D.
• Bocobza, S. E.
• Unger, T.
• Malitsky, S.
• Finkers, R.
• Tikunov, Y.
• Bovy, A.
• Chikate, Y.
• Singh, P.
• Rogachev, I.
• Beekwilder, J.
• Giri, A. P.
• Aharoni, A.

Titel

Biosynthesis of Antinutritional Alkaloids in Solanaceous Crops Is Mediated by Clustered Genes

Ist Teil von

• Science (American Association for the Advancement of Science), 2013-07, Vol.341 (6142), p.175-179

Ort / Verlag

United States: American Association for the Advancement of Science

Erscheinungsjahr

2013

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Steroidal glycoalkaloids (SGAs) such as α-solanine found in solanaceous food plants— as, for example, potato— are antinutritional factors for humans. Comparative coexpression analysis between tomato and potato coupled with chemical profiling revealed an array of 10 genes that partake in SGA biosynthesis. We discovered that six of them exist as a cluster on chromosome 7, whereas an additional two are adjacent in a duplicated genomic region on chromosome 12. Following systematic functional analysis, we suggest a revised SGA biosynthetic pathway starting from cholesterol up to the tetrasaccharide moiety linked to the tomato SGA aglycone. Silencing GLYCOALKALOID METABOLISM 4 prevented accumulation of SGAs in potato tubers and tomato fruit. This may provide a means for removal of unsafe, antinutritional substances present in these widely used food crops.