Science (American Association for the Advancement of Science), 2019-06, Vol.364 (6444), p.971
- Soldatov, Ruslan
- Kaucka, Marketa
- Kastriti, Maria Eleni
- Petersen, Julian
- Chontorotzea, Tatiana
- Englmaier, Lukas
- Akkuratova, Natalia
- Yang, Yunshi
- Häring, Martin
- Dyachuk, Viacheslav
- Bock, Christoph
- Farlik, Matthias
- Piacentino, Michael L
- Boismoreau, Franck
- Hilscher, Markus M
- Yokota, Chika
- Qian, Xiaoyan
- Nilsson, Mats
- Bronner, Marianne E
- Croci, Laura
- Hsiao, Wen-Yu
- Guertin, David A
- Brunet, Jean-Francois
- Consalez, Gian Giacomo
- Ernfors, Patrik
- Fried, Kaj
- Kharchenko, Peter V
- Adameyko, Igor
2019
Details
- Autor(en) / Beteiligte
- Soldatov, Ruslan
- Kaucka, Marketa
- Kastriti, Maria Eleni
- Petersen, Julian
- Chontorotzea, Tatiana
- Englmaier, Lukas
- Akkuratova, Natalia
- Yang, Yunshi
- Häring, Martin
- Dyachuk, Viacheslav
- Bock, Christoph
- Farlik, Matthias
- Piacentino, Michael L
- Boismoreau, Franck
- Hilscher, Markus M
- Yokota, Chika
- Qian, Xiaoyan
- Nilsson, Mats
- Bronner, Marianne E
- Croci, Laura
- Hsiao, Wen-Yu
- Guertin, David A
- Brunet, Jean-Francois
- Consalez, Gian Giacomo
- Ernfors, Patrik
- Fried, Kaj
- Kharchenko, Peter V
- Adameyko, Igor
- Titel
- Spatiotemporal structure of cell fate decisions in murine neural crest
- Ist Teil von
- Science (American Association for the Advancement of Science), 2019-06, Vol.364 (6444), p.971
- Ort / Verlag
- United States: The American Association for the Advancement of Science
- Erscheinungsjahr
- 2019
- Link zum Volltext
- Quelle
- American Association for the Advancement of Science
- Beschreibungen/Notizen
- Neural crest cells are embryonic progenitors that generate numerous cell types in vertebrates. With single-cell analysis, we show that mouse trunk neural crest cells become biased toward neuronal lineages when they delaminate from the neural tube, whereas cranial neural crest cells acquire ectomesenchyme potential dependent on activation of the transcription factor The choices that neural crest cells make to become sensory, glial, autonomic, or mesenchymal cells can be formalized as a series of sequential binary decisions. Each branch of the decision tree involves initial coactivation of bipotential properties followed by gradual shifts toward commitment. Competing fate programs are coactivated before cells acquire fate-specific phenotypic traits. Determination of a specific fate is achieved by increased synchronization of relevant programs and concurrent repression of competing fate programs.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075, 1095-9203eISSN: 1095-9203DOI: 10.1126/science.aas9536Titel-ID: cdi_swepub_primary_oai_prod_swepub_kib_ki_se_141103678
- Format
- –
- Schlagworte
- Animals, Autonomic nervous system, Basic Helix-Loop-Helix Transcription Factors - metabolism, Bias, Bifurcations, Bones, Cartilage, Cell fate, Cell Lineage, Cells (biology), Decision trees, Delamination, Developmental Programs, Embryos, Epigenetics, Gene expression, Gene Expression Regulation, Developmental, Gene sequencing, Genes, Heterogeneity, Medicin och hälsovetenskap, Melanocytes, Mesenchymal Stem Cells - cytology, Mesenchymal Stem Cells - metabolism, Mesenchyme, Mice, Mice, Mutant Strains, Migration, Molecular modelling, Nerve Tissue Proteins - metabolism, Neural crest, Neural Crest - cytology, Neural Crest - embryology, Neural Crest - metabolism, Neural stem cells, Neural Stem Cells - cytology, Neural Stem Cells - metabolism, Neural tube, Neural Tube - cytology, Neural Tube - embryology, Neurogenesis - genetics, Neuroglia - cytology, Neuronal-glial interactions, Neurons - cytology, Nuclear Proteins - metabolism, Phox2b protein, Progenitor cells, Progeny, Progressions, Regulators, Ribonucleic acid, RNA, Single-Cell Analysis, Skull, Spatial analysis, Statistical analysis, Stochasticity, Synchronism, Synchronization, Teeth, Trajectory analysis, Transcription activation, Twist-Related Protein 1 - metabolism, Vertebrates