Details

Autor(en) / Beteiligte

• Ohlsson, Claes
• Hägg, Daniel A
• Hammarhjelm, Fredrik
• Dalmau Gasull, Adrià
• Bellman, Jakob
• Windahl, Sara H
• Palsdottir, Vilborg
• Jansson, John-Olov

Titel

The Gravitostat Regulates Fat Mass in Obese Male Mice While Leptin Regulates Fat Mass in Lean Male Mice

Ist Teil von

• Endocrinology (Philadelphia), 2018-07, Vol.159 (7), p.2676-2682

Ort / Verlag

Washington, DC: Endocrine Society

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Abstract Leptin has been the only known homeostatic regulator of fat mass, but we recently found evidence for a second one, named the gravitostat. In the current study, we compared the effects of leptin and increased loading (gravitostat stimulation) on fat mass in mice with different levels of body weight (lean, overweight, and obese). Leptin infusion suppressed body weight and fat mass in lean mice given normal chow but not in overweight or obese mice given a high-fat diet for 4 and 8 weeks, respectively. The maximum effect of leptin on body weight and fat mass was obtained already at <44 ng/mL of serum leptin. Increased loading using intraperitoneal capsules with different weights decreased body weight in overweight and obese mice. Although the implantation of an empty capsule reduced the body weight in lean mice, only a nonsignificant tendency of a specific effect of increased loading was observed in the lean mice. These findings demonstrate that the gravitostat regulates fat mass in obese mice, whereas leptin regulates fat mass only in lean mice with low endogenous serum leptin levels. We propose that activation of the gravitostat primarily protects against obesity, whereas low levels of leptin protect against undernutrition. We compared the effects of leptin and gravitostat stimulation on body weight in lean and obese mice. The gravitostat reduced body weight in obese mice, whereas leptin reduced body weight in lean mice.