Details

Autor(en) / Beteiligte

• Perez, Laura
• Wolf, Kathrin
• Hennig, Frauke
• Penell, Johanna
• Basagaña, Xavier
• Foraster, Maria
• Aguilera, Inmaculada
• Agis, David
• Beelen, Rob
• Brunekreef, Bert
• Cyrys, Josef
• Fuks, Kateryna B
• Adam, Martin
• Baldassarre, Damiano
• Cirach, Marta
• Elosua, Roberto
• Dratva, Julia
• Hampel, Regina
• Koenig, Wolfgang
• Marrugat, Jaume
• de Faire, Ulf
• Pershagen, Göran
• Probst-Hensch, Nicole M
• de Nazelle, Audrey
• Nieuwenhuijsen, Mark J
• Rathmann, Wolfgang
• Rivera, Marcela
• Seissler, Jochen
• Schindler, Christian
• Thiery, Joachim
• Hoffmann, Barbara
• Peters, Annette
• Künzli, Nino

Titel

Air pollution and atherosclerosis: a cross-sectional analysis of four European cohort studies in the ESCAPE study

Ist Teil von

• Environmental health perspectives, 2015-06, Vol.123 (6), p.597-597

Ort / Verlag

United States: National Institute of Environmental Health Sciences

Erscheinungsjahr

2015

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• In four European cohorts, we investigated the cross-sectional association between long-term exposure to air pollution and intima-media thickness of the common carotid artery (CIMT), a preclinical marker of atherosclerosis. Individually assigned levels of nitrogen dioxide, nitrogen oxides, particulate matter ≤ 2.5 μm (PM2.5), absorbance of PM2.5 (PM2.5abs), PM10, PMcoarse, and two indicators of residential proximity to highly trafficked roads were obtained under a standard exposure protocol (European Study of Cohorts for Air Pollution Effects-ESCAPE study) in the Stockholm area (Sweden), the Ausburg and Ruhr area (Germany), and the Girona area (Spain). We used linear regression and meta-analyses to examine the association between long-term exposure to air pollution and CIMT. The meta-analysis with 9,183 individuals resulted in an estimated increase in CIMT (geometric mean) of 0.72% (95% CI: -0.65%, 2.10%) per 5-μg/m3 increase in PM2.5 and 0.42% (95% CI: -0.46%, 1.30%) per 10-5/m increase in PM2.5abs. Living in proximity to high traffic was also positively but not significantly associated with CIMT. Meta-analytic estimates for other pollutants were inconsistent. Results were similar across different adjustment sets and sensitivity analyses. In an extended meta-analysis for PM2.5 with three other previously published studies, a 0.78% (95% CI: -0.18%, 1.75%) increase in CIMT was estimated for a 5-μg/m3 contrast in PM2.5. Using a standardized exposure and analytical protocol in four European cohorts, we found that cross-sectional associations between CIMT and the eight ESCAPE markers of long-term residential air pollution exposure did not reach statistical significance. The additional meta-analysis of CIMT and PM2.5 across all published studies also was positive but not significant.