Details

Autor(en) / Beteiligte

• Ghensi, Paolo
• Manghi, Paolo
• Zolfo, Moreno
• Armanini, Federica
• Pasolli, Edoardo
• Bolzan, Mattia
• Bertelle, Alberto
• Dell’Acqua, Federico
• Dellasega, Ester
• Waldner, Romina
• Tessarolo, Francesco
• Tomasi, Cristiano
• Segata, Nicola

Titel

Strong oral plaque microbiome signatures for dental implant diseases identified by strain-resolution metagenomics

Ist Teil von

• NPJ biofilms and microbiomes, 2020-10, Vol.6 (1), p.47-47, Article 47

Ort / Verlag

London: Nature Publishing Group

Erscheinungsjahr

2020

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Abstract Dental implants are installed in an increasing number of patients. Mucositis and peri-implantitis are common microbial–biofilm-associated diseases affecting the tissues that surround the dental implant and are a major medical and socioeconomic burden. By metagenomic sequencing of the plaque microbiome in different peri-implant health and disease conditions (113 samples from 72 individuals), we found microbial signatures for peri-implantitis and mucositis and defined the peri-implantitis-related complex (PiRC) composed by the 7 most discriminative bacteria. The peri-implantitis microbiome is site specific as contralateral healthy sites resembled more the microbiome of healthy implants, while mucositis was specifically enriched for Fusobacterium nucleatum acting as a keystone colonizer. Microbiome-based machine learning showed high diagnostic and prognostic power for peri-implant diseases and strain-level profiling identified a previously uncharacterized subspecies of F. nucleatum to be particularly associated with disease. Altogether, we associated the plaque microbiome with peri-implant diseases and identified microbial signatures of disease severity.