Nature Medicine, 2020-05, Vol.26 (5), p.681-687
2020
Details
- Autor(en) / Beteiligte
- Titel
- SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes
- Ist Teil von
- Nature Medicine, 2020-05, Vol.26 (5), p.681-687
- Ort / Verlag
- United States: Nature Publishing Group
- Erscheinungsjahr
- 2020
- Link zum Volltext
- Quelle
- EZB Electronic Journals Library
- Beschreibungen/Notizen
- We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells' potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1078-8956, 1546-170XeISSN: 1546-170X, 1744-7933DOI: 10.1038/s41591-020-0868-6Titel-ID: cdi_swepub_primary_oai_DiVA_org_kth_273986
- Format
- –
- Schlagworte
- ACE2, Analysis, Angiotensin-converting enzyme 2, atp10b protein, c15orf48 protein, cathepsin B, cathepsin L, cdc42ep5 protein, colon tissue, comparative study, Cornea, cornea epithelium, cornea tissue, coronavirus disease 2019, COVID-19, crym protein, cyp2f1 protein, Disease transmission, duoxa2 protein, Epithelial cells, epithelium cell, esophagus tissue, fam3d protein, fcgbp protein, fetus, fetus tissue, Gene expression, gene expression level, Gene sequencing, Genes, Genetic aspects, heart tissue, human, human cell, Human immunogenetics, human tissue, ido1 protein, ileum tissue, Immune clearance, immune response gene, Immunity, Innate immunity, Intestine, kidney tissue, Life Sciences, liver tissue, lypd2 protein, marker gene, messenger RNA, muscle tissue, mx1 protein, nose epithelium, oas1 protein, pancreas tissue, priority journal, prkar2b protein, prostate stem cell antigen, prostate tissue, protein, protein S 100, proteinase, rarres1 protein, retina tissue, Ribonucleic acid, RNA, Severe acute respiratory syndrome, Severe acute respiratory syndrome coronavirus 2, single cell RNA seq, skeletal muscle, slc5a8 protein, spdef protein, spleen tissue, st3gal4 enzyme, st6gal1 enzyme, Surveying, testis tissue, tmprss2 protein, Transcriptomics, Tropism, ube2l6 protein, unclassified drug, Viral diseases, viral tropism, virus entry, virus enzyme, virus transmission, vitronectin