Details

Autor(en) / Beteiligte

• Marchi, Saverio
• Bittremieux, Mart
• Missiroli, Sonia
• Morganti, Claudia
• Patergnani, Simone
• Sbano, Luigi
• Rimessi, Alessandro
• Kerkhofs, Martijn
• Parys, Jan B.
• Bultynck, Geert
• Giorgi, Carlotta
• Pinton, Paolo

Titel

Endoplasmic Reticulum-Mitochondria Communication Through Ca2+ Signaling: The Importance of Mitochondria-Associated Membranes (MAMs)

Ist Teil von

• Organelle Contact Sites, 2017, p.49-67

Ort / Verlag

Singapore: Springer Singapore

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The execution of proper Ca2+ signaling requires close apposition between the endoplasmic reticulum (ER) and mitochondria. Hence, Ca2+ released from the ER is “quasi-synaptically” transferred to mitochondrial matrix, where Ca2+ stimulates mitochondrial ATP synthesis by activating the tricarboxylic acid (TCA) cycle. However, when the Ca2+ transfer is excessive and sustained, mitochondrial Ca2+ overload induces apoptosis by opening the mitochondrial permeability transition pore. A large number of regulatory proteins reside at mitochondria-associated ER membranes (MAMs) to maintain the optimal distance between the organelles and to coordinate the functionality of both ER and mitochondrial Ca2+ transporters or channels. In this chapter, we discuss the different pathways involved in the regulation of ER-mitochondria Ca2+ flux and describe the activities of the various Ca2+ players based on their primary intra-organelle localization.