Details

Autor(en) / Beteiligte

• Roden, Dan M.
• Shoemaker, M. Benjamin

Titel

Genomics of Cardiac Arrhythmias

Ist Teil von

• Cardiac Arrhythmias, Pacing and Sudden Death, 2017, p.27-36

Ort / Verlag

Switzerland: Springer International Publishing AG

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• It has long been recognized that certain traits “run in families”, and arrhythmias are no exception. The most poignant examples are channelopathies and cardiomyopathies which can take the life of an otherwise healthy child. The current state of knowledge in channelopathies and cardiomyopathies is outlined in other chapters in this volume and the details of the specific genes in these diseases will not be discussed further here. Increasingly robust datasets also support the idea that genetic factors play a role in variable drug responses and in susceptibility to common arrhythmias notably atrial fibrillation (AF) and sudden cardiac death (SCD). Further, inexpensive and accurate genotyping and sequencing technologies introduced in the last decade are revolutionizing not only diagnostics and patient care, but are also introducing new complexities in interpretation of genetic test data with which physicians are only now becoming aware.