Details

Autor(en) / Beteiligte

• Hawkins, M Brent
• Jandzik, David
• Tulenko, Frank J
• Cass, Amanda N
• Nakamura, Tetsuya
• Shubin, Neil H
• Davis, Marcus C
• Stock, David W

Titel

An Fgf-Shh positive feedback loop drives growth in developing unpaired fins

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 2022-03, Vol.119 (10), p.e2120150119-e2120150119

Ort / Verlag

United States: National Academy of Sciences

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• The origin and diversification of appendage types is a central question in vertebrate evolution. Understanding the genetic mechanisms that underlie fin and limb development can reveal relationships between different appendages. Here we demonstrate, using chemical genetics, a mutually agonistic interaction between Fgf and Shh genes in the developing dorsal fin of the channel catfish, . We also find that Fgf8 and Shh orthologs are expressed in the apical ectodermal ridge and zone of polarizing activity, respectively, in the median fins of representatives from other major vertebrate lineages. These findings demonstrate the importance of this feedback loop in median fins and offer developmental evidence for a median fin-first scenario for vertebrate paired appendage origins.