Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Head-to-head intra-individual comparison of biodistribution and tumor uptake of 68Ga-FAPI and 18F-FDG PET/CT in cancer patients
Ist Teil von
European journal of nuclear medicine and molecular imaging, 2021-12, Vol.48 (13), p.4377-4385
Ort / Verlag
Berlin/Heidelberg: Springer Berlin Heidelberg
Erscheinungsjahr
2021
Link zum Volltext
Quelle
SpringerLink
Beschreibungen/Notizen
Purpose
FAPI ligands (fibroblast activation protein inhibitor), a novel class of radiotracers for PET/CT imaging, demonstrated in previous studies rapid and high tumor uptake. The purpose of this study is the head-to-head intra-individual comparison of
68
Ga-FAPI versus standard-of-care
18
F-FDG in PET/CT in organ biodistribution and tumor uptake in patients with various cancers.
Material and Methods
This international retrospective multicenter analysis included PET/CT data from 71 patients from 6 centers who underwent both
68
Ga-FAPI and
18
F-FDG PET/CT within a median time interval of 10 days (range 1–89 days). Volumes of interest (VOIs) were manually drawn in normal organs and tumor lesions to quantify tracer uptake by SUVmax and SUVmean. Furthermore, tumor-to-background ratios (TBR) were generated (SUVmax tumor/ SUVmax organ).
Results
A total of 71 patients were studied of, which 28 were female and 43 male (median age 60). In 41 of 71 patients, the primary tumor was present. Forty-three of 71 patients exhibited 162 metastatic lesions.
68
Ga-FAPI uptake in primary tumors and metastases was comparable to
18
F-FDG in most cases. The SUVmax was significantly lower for
68
Ga-FAPI than
18
F-FDG in background tissues such as the brain, oral mucosa, myocardium, blood pool, liver, pancreas, and colon. Thus,
68
Ga-FAPI TBRs were significantly higher than
18
F-FDG TBRs in some sites, including liver and bone metastases.
Conclusion
Quantitative tumor uptake is comparable between
68
Ga-FAPI and
18
F-FDG, but lower background uptake in most normal organs results in equal or higher TBRs for
68
Ga-FAPI. Thus,
68
Ga-FAPI PET/CT may yield improved diagnostic information in various cancers and especially in tumor locations with high physiological
18
F-FDG uptake.