Details

Autor(en) / Beteiligte

• Aul, Dr Raminder
• Gates, Dr Jessica
• Draper, Dr Adrian
• Dunleavy, Dr Anne
• Ruickbie, Dr Sachelle
• Meredith, Dr Helen
• Walters, Dr Nicola
• van Zeller, Dr Cristiano
• Taylor, Dr Victoria
• Bridgett, Dr Michael
• Dunwoody, Dr Roisin
• Grubnic, Dr Sisa
• Jacob, Dr Tersesa
• Ean Ong, Dr Yee

Titel

Complications after discharge with COVID-19 infection and risk factors associated with development of post-COVID pulmonary fibrosis

Ist Teil von

• Respiratory medicine, 2021-11, Vol.188, p.106602-106602, Article 106602

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Survivors of COVID-19 infection may develop post-covid pulmonary fibrosis (PCF) and suffer from long term multi-system complications. The magnitude and risk factors associated with these are unknown. We investigated the prevalence and risk factors associated with PCF and other complications in patients discharged after COVID-19 infection. Patients had phone assessment 6 weeks post hospital discharge after COVID-19 infection using a set protocol. Those with significant respiratory symptoms were investigated with a CTPA, Pulmonary Function Tests and echocardiogram. Prevalence of myalgia, fatigue, psychological symptoms and PCF was obtained. Risk factors associated with these were investigated. A large number of patients had persistent fatigue (45.1%), breathlessness (36.5%), myalgia (20.5%) and psychological symptoms (19.5%). PCF was seen in 9.5% of the patients and was associated with persistent breathlessness at 6 weeks and inpatient ventilation [adjusted OR 5.02(1.76–14.27) and 4.45(1.27–15.58)] respectively. It was more common in men and in patients with peak CRP >171.5 mg/L, peak WBC count ≥12 × 10 9/L, severe inpatient COVID-19 CXR changes and CT changes. Ventilation was also a risk factor for persisting fatigue and myalgia, the latter was also more common in those with severe cytokine storm and severe COVID-19 inpatient CXR changes. All the patients discharged after COVID-19 should be assessed using a set protocol by a multidisciplinary team. Patients who had severe COVID-19 infection particularly those who were intubated and who have persistent breathlessness are at risk of developing PCF. They should have a CT Chest and have respiratory follow-up. •Persistent fatigue, breathlessness and myalgia are common after COVID-19 infection.•9.3% of the patients with persistent respiratory symptoms have Post Covid Pulmonary Fibrosis (PCF).•Breathlessness at 6 weeks and prior intubation are the strongest risk factors associated with PCF.