Details

Autor(en) / Beteiligte

• Mazur, Natalie I
• Löwensteyn, Yvette N
• Willemsen, Joukje E
• Gill, Christopher J
• Forman, Leah
• Mwananyanda, Lawrence M
• Blau, Dianna M
• Breiman, Robert F
• Madhi, Shabir A
• Mahtab, Sana
• Gurley, Emily S
• El Arifeen, Shams
• Assefa, Nega
• Scott, J Anthony G
• Onyango, Dickens
• Tippet Barr, Beth A
• Kotloff, Karen L
• Sow, Samba O
• Mandomando, Inacio
• Ogbuanu, Ikechukwu
• Jambai, Amara
• Bassat, Quique
• Caballero, Mauricio T
• Polack, Fernando P
• Omer, Saad
• Kazi, Abdul Momin
• Simões, Eric A F
• Satav, Ashish
• Bont, Louis J

Titel

Global Respiratory Syncytial Virus–Related Infant Community Deaths

Ist Teil von

• Clinical infectious diseases, 2021-09, Vol.73 (Supplement_3), p.S229-S237

Ort / Verlag

US: Oxford University Press

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Abstract Background Respiratory syncytial virus (RSV) is a leading cause of pediatric death, with >99% of mortality occurring in low- and lower middle-income countries. At least half of RSV-related deaths are estimated to occur in the community, but clinical characteristics of this group of children remain poorly characterized. Methods The RSV Global Online Mortality Database (RSV GOLD), a global registry of under-5 children who have died with RSV-related illness, describes clinical characteristics of children dying of RSV through global data sharing. RSV GOLD acts as a collaborative platform for global deaths, including community mortality studies described in this supplement. We aimed to compare the age distribution of infant deaths <6 months occurring in the community with in-hospital. Results We studied 829 RSV-related deaths <1 year of age from 38 developing countries, including 166 community deaths from 12 countries. There were 629 deaths that occurred <6 months, of which 156 (25%) occurred in the community. Among infants who died before 6 months of age, median age at death in the community (1.5 months; IQR: 0.8−3.3) was lower than in-hospital (2.4 months; IQR: 1.5−4.0; P < .0001). The proportion of neonatal deaths was higher in the community (29%, 46/156) than in-hospital (12%, 57/473, P < 0.0001). Conclusions We observed that children in the community die at a younger age. We expect that maternal vaccination or immunoprophylaxis against RSV will have a larger impact on RSV-related mortality in the community than in-hospital. This case series of RSV-related community deaths, made possible through global data sharing, allowed us to assess the potential impact of future RSV vaccines. The global age distribution of RSV-related deaths in the community is unknown. Children dying of RSV in the community are younger than children dying in-hospital in developing countries. We expect the impact of RSV prevention via maternal vaccination or monoclonal antibody prophylaxis on mortality in early life to be higher for community than in-hospital RSV-related deaths.