Details

Autor(en) / Beteiligte

• Mehri, Fereshteh
• Rahbar, Amir Hossein
• Ghane, Elaheh Talebi
• Souri, Bahram
• Esfahani, Maryam

Titel

Changes in oxidative markers in COVID-19 patients

Ist Teil von

• Archives of medical research, 2021-11, Vol.52 (8), p.843-849

Ort / Verlag

Elsevier Inc

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• •Covid-19 is a disease with an unknown mechanism•Malondialdehyde (MDA), total oxidant status (TOS), activity of catalase (CAT) and super oxide dismutase (SOD) biomarkers level were measured in different patients with Covid-19•There was a significant relationship between levels of oxidative stress in and severity of patients with Covid-19.•Different strategies for reducing or preventing of oxidative stress may help in Covid-19 managements. Covid-19 has been as an important human infectious disease that has affected several countries. Cytokine storm has major role is Covid-19 pathogenesis. The association between inflammation and oxidative stress is well stablished. In this article, we aim to assess oxidative stress markers in Covid-19 patients compare to the healthy subjects. A total of 48 persons (24 with Covid-19 and 24 controls) were evaluated in this research. Serum oxidative stress markers including Malondialdehyde (MDA), total oxidant status (TOS), activity of catalase (CAT) and super oxide dismutase (SOD) were measured alongside routine laboratory tests. Patients group were divided into ICU and Non-ICU groups. ESR, CRP and serum level of ferritin were significantly higher in case group. Serum level of albumin was significantly lower in Covid-19 patients. Serum MDA and TOS was significantly increased in Covid-19 patients. Also, Covid-19 patients had higher serum activity of CAT and GPX. Oxidative stress markers are significantly elevated in Covid-19 patients. This may have significant role in mechanism of disease development. In the fight against Covid-19, as a global struggle, all possible treatments demand more attention. So, Covid-19 patients may benefit from strategies for reducing or preventing oxidative stress.