Details

Autor(en) / Beteiligte

• Washington, Nicole L.
• Gangavarapu, Karthik
• Zeller, Mark
• Bolze, Alexandre
• Cirulli, Elizabeth T.
• Schiabor Barrett, Kelly M.
• Larsen, Brendan B.
• Anderson, Catelyn
• White, Simon
• Cassens, Tyler
• Jacobs, Sharoni
• Levan, Geraint
• Nguyen, Jason
• Ramirez, Jimmy M.
• Rivera-Garcia, Charlotte
• Sandoval, Efren
• Wang, Xueqing
• Wong, David
• Spencer, Emily
• Robles-Sikisaka, Refugio
• Kurzban, Ezra
• Hughes, Laura D.
• Deng, Xianding
• Wang, Candace
• Servellita, Venice
• Valentine, Holly
• De Hoff, Peter
• Seaver, Phoebe
• Sathe, Shashank
• Gietzen, Kimberly
• Sickler, Brad
• Antico, Jay
• Hoon, Kelly
• Liu, Jingtao
• Harding, Aaron
• Bakhtar, Omid
• Basler, Tracy
• Austin, Brett
• MacCannell, Duncan
• Isaksson, Magnus
• Febbo, Phillip G.
• Becker, David
• Laurent, Marc
• McDonald, Eric
• Yeo, Gene W.
• Knight, Rob
• Laurent, Louise C.
• de Feo, Eileen
• Worobey, Michael
• Chiu, Charles Y.
• Suchard, Marc A.
• Lu, James T.
• Lee, William
• Andersen, Kristian G.

Titel

Emergence and rapid transmission of SARS-CoV-2 B.1.1.7 in the United States

Ist Teil von

• Cell, 2021-05, Vol.184 (10), p.2587-2594.e7

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• The highly transmissible B.1.1.7 variant of SARS-CoV-2, first identified in the United Kingdom, has gained a foothold across the world. Using S gene target failure (SGTF) and SARS-CoV-2 genomic sequencing, we investigated the prevalence and dynamics of this variant in the United States (US), tracking it back to its early emergence. We found that, while the fraction of B.1.1.7 varied by state, the variant increased at a logistic rate with a roughly weekly doubling rate and an increased transmission of 40%–50%. We revealed several independent introductions of B.1.1.7 into the US as early as late November 2020, with community transmission spreading it to most states within months. We show that the US is on a similar trajectory as other countries where B.1.1.7 became dominant, requiring immediate and decisive action to minimize COVID-19 morbidity and mortality. [Display omitted] •The B.1.1.7 is ∼50% more transmissible than other circulating lineages in the US•The proportion of cases caused by B.1.1.7 is increasing at a rate of ∼7.5% per day•Several independent introductions of B.1.1.7 occurred in early December 2020•We estimate that B.1.1.7 will become dominant in many US states by late March 2021 Genomic epidemiology analyses explain the introduction and transmission of the B.1.1.7 variant of SARS-CoV-2 into the US, with projections for it to soon be the dominant strain in the country.