Mucosal immunology, 2021-03, Vol.14 (2), p.279-281
2021
Details
- Autor(en) / Beteiligte
- Titel
- Comment on "ILC1 drive intestinal epithelial and matrix remodeling"
- Ist Teil von
- Mucosal immunology, 2021-03, Vol.14 (2), p.279-281
- Ort / Verlag
- United States: Nature Publishing Group
- Erscheinungsjahr
- 2021
- Link zum Volltext
- Quelle
- Alma/SFX Local Collection
- Beschreibungen/Notizen
- Type 1 Innate lymphoid cells (ILC1) accumulate in the inflamed mucosa of patients with Crohn’s disease (CD) but their role in CD pathogenesis remains poorly known. In a recent issue of Nature materials, Jowett et al. (Nat. Mat. 2020) used a coculture model with intestinal organoids to show that ILC1 could promote intestinal epithelial growth and tissue remodeling through an unexpected mechanism that involves the transforming growth factor 1 (TGF-β1) and the metalloproteinase MMP9.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1933-0219eISSN: 1935-3456DOI: 10.1038/s41385-020-00360-9Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7946633
- Format
- –
- Schlagworte
- Cadmium, Cell growth, Comment, Crohn's disease, Cytokines, Dendritic cells, Epigenetics, Fibroblasts, Gelatinase B, Glycoproteins, Infections, Inflammation, Inflammatory bowel disease, Intestine, Intestines, Investigations, Killer Cells, Natural, Kinases, Life Sciences, Lymphoid cells, Metalloproteinase, Mucosa, Organoids, Pathogenesis, Physiology, Transforming growth factor-b1