Science (American Association for the Advancement of Science), 2020-02, Vol.367 (6478)
2020
Details
- Autor(en) / Beteiligte
- Titel
- The biology , function , and biomedical applications of exosomes
- Ist Teil von
- Science (American Association for the Advancement of Science), 2020-02, Vol.367 (6478)
- Ort / Verlag
- United States: The American Association for the Advancement of Science
- Erscheinungsjahr
- 2020
- Link zum Volltext
- Quelle
- American Association for the Advancement of Science
- Beschreibungen/Notizen
- The study of extracellular vesicles (EVs) has the potential to identify unknown cellular and molecular mechanisms in intercellular communication and in organ homeostasis and disease. Exosomes, with an average diameter of ~100 nanometers, are a subset of EVs. The biogenesis of exosomes involves their origin in endosomes, and subsequent interactions with other intracellular vesicles and organelles generate the final content of the exosomes. Their diverse constituents include nucleic acids, proteins, lipids, amino acids, and metabolites, which can reflect their cell of origin. In various diseases, exosomes offer a window into altered cellular or tissue states, and their detection in biological fluids potentially offers a multicomponent diagnostic readout. The efficient exchange of cellular components through exosomes can inform their applied use in designing exosome-based therapeutics.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.aau6977Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7717626
- Format
- –
- Schlagworte
- Abnormalities, Aging, Aging (natural), Amino acids, Anatomy, Animal models, Animals, Antisense oligonucleotides, Antisense RNA, Bioavailability, Bioelectricity, Biological effects, Biology, Biomedical materials, Biopsy, Biosynthesis, Cancer, Cardiovascular diseases, Cardiovascular Diseases - metabolism, Cardiovascular system, Cell Communication, Cell interactions, Cell surface, Central nervous system, Chemotherapy, Communication, Communication (Thought Transfer), Computational fluid dynamics, Deoxyribonucleic acid, Diagnosis, Disease, DNA, Eukaryotes, Exosomes - chemistry, Exosomes - metabolism, Exosomes - physiology, Extracellular vesicles, Feedback (Response), Fluids, Heterogeneity, Homeostasis, Humans, Immune response, Infections - immunology, Lipids, Membranes, Metabolic Diseases - metabolism, Metabolites, Modulators, Neoplasms - metabolism, Neurodegeneration, Neurodegenerative diseases, Neurodegenerative Diseases - metabolism, Nucleic acids, Organelles, Organs, Pathogenicity, Pathogens, Payloads, Pharmacokinetics, Pregnancy, Prokaryotes, Proteins, Reproduction, Ribonucleic acid, RNA, Senescence, Vesicles