Details

Autor(en) / Beteiligte

• Sasazuki, Shizuka
• Charvat, Hadrien
• Hara, Azusa
• Wakai, Kenji
• Nagata, Chisato
• Nakamura, Kozue
• Tsuji, Ichiro
• Sugawara, Yumi
• Tamakoshi, Akiko
• Matsuo, Keitaro
• Oze, Isao
• Mizoue, Tetsuya
• Tanaka, Keitaro
• Inoue, Manami
• Tsugane, Shoichiro

Titel

Diabetes mellitus and cancer risk: Pooled analysis of eight cohort studies in Japan

Ist Teil von

• Cancer science, 2013-11, Vol.104 (11), p.1499-1507

Ort / Verlag

England: John Wiley & Sons, Inc

Erscheinungsjahr

2013

Link zum Volltext

Quelle

Wiley Blackwell Single Titles

Beschreibungen/Notizen

• Although a growing body of evidence suggests a link between diabetes and cancer, it is not clear whether diabetes independently increases the risk of cancer. We conducted a comprehensive assessment of the association between pre‐existing diabetes and total and site‐specific cancer risk based on a pooled analysis of eight cohort studies in Japan (>330 000 subjects). We estimated a summary hazard ratio by pooling study‐specific hazard ratios for total and site‐specific cancer by using a random‐effects model. A statistically increased risk was observed for cancers at specific sites, such as colon (hazard ratio; HR = 1.40), liver (HR = 1.97), pancreas (HR = 1.85) and bile duct (HR = 1.66; men only). Increased risk was also suggested for other sites, and diabetes mellitus was associated with an overall 20% increased risk in total cancer incidence in the Japanese population. The association between these two diseases has important implications for reiterating the importance of controlling lifestyle factors and may suggest a possible strategy for cancer screening among patients with diabetes. Studies continuously investigating the risk factors for diabetes are also important.