The New England journal of medicine, 2020-12, Vol.383 (25), p.2439-2450
- Walsh, Edward E
- Frenck, Robert W
- Falsey, Ann R
- Kitchin, Nicholas
- Absalon, Judith
- Gurtman, Alejandra
- Lockhart, Stephen
- Neuzil, Kathleen
- Mulligan, Mark J
- Bailey, Ruth
- Swanson, Kena A
- Li, Ping
- Koury, Kenneth
- Kalina, Warren
- Cooper, David
- Fontes-Garfias, Camila
- Shi, Pei-Yong
- Türeci, Özlem
- Tompkins, Kristin R
- Lyke, Kirsten E
- Raabe, Vanessa
- Dormitzer, Philip R
- Jansen, Kathrin U
- Şahin, Uğur
- Gruber, William C
2020
Details
- Autor(en) / Beteiligte
- Walsh, Edward E
- Frenck, Robert W
- Falsey, Ann R
- Kitchin, Nicholas
- Absalon, Judith
- Gurtman, Alejandra
- Lockhart, Stephen
- Neuzil, Kathleen
- Mulligan, Mark J
- Bailey, Ruth
- Swanson, Kena A
- Li, Ping
- Koury, Kenneth
- Kalina, Warren
- Cooper, David
- Fontes-Garfias, Camila
- Shi, Pei-Yong
- Türeci, Özlem
- Tompkins, Kristin R
- Lyke, Kirsten E
- Raabe, Vanessa
- Dormitzer, Philip R
- Jansen, Kathrin U
- Şahin, Uğur
- Gruber, William C
- Titel
- Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates
- Ist Teil von
- The New England journal of medicine, 2020-12, Vol.383 (25), p.2439-2450
- Ort / Verlag
- United States: Massachusetts Medical Society
- Erscheinungsjahr
- 2020
- Link zum Volltext
- Quelle
- Alma/SFX Local Collection
- Beschreibungen/Notizen
- Two doses 3 weeks apart of a lipid nanoparticle, nucleoside-modified RNA vaccine encoding a trimerized SARS-CoV-2 receptor–binding domain elicited high levels of antigen-binding and virus-neutralizing antibodies in adults 18 to 55 years and 65 to 85 years of age. Reactogenicity was moderate and transient. Large trials are ongoing.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0028-4793eISSN: 1533-4406DOI: 10.1056/NEJMoa2027906Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7583697
- Format
- –
- Schlagworte
- Adolescent, Adult, Age, Aged, Aged, 80 and over, Antibodies, Viral - blood, Confidence intervals, Conformation, Coronaviridae, Coronaviruses, COVID-19, COVID-19 - immunology, COVID-19 - prevention & control, COVID-19 vaccines, COVID-19 Vaccines - adverse effects, COVID-19 Vaccines - immunology, Female, Hepatitis, Humans, Immunogenicity, Infections, Injections, Intramuscular - adverse effects, Laboratories, Male, Middle Aged, Nanoparticles, Neutralization Tests, Original, Pandemics, Ribonucleic acid, RNA, Safety, SARS-CoV-2 - immunology, Severe acute respiratory syndrome coronavirus 2, Single-Blind Method, Spike Glycoprotein, Coronavirus, Statistical analysis, Vaccines, Young Adult