Details

Autor(en) / Beteiligte

• Nguyen, Van Thu
• Rivière, Philippe
• Ripoll, Pierre
• Barnier, Julien
• Vuillemot, Romain
• Ferrand, Gabriel
• Cohen-Boulakia, Sarah
• Ravaud, Philippe
• Boutron, Isabelle
• Alawadhi, Solaf
• Amer-Yahia, Sihem
• Ávila, Camila
• Bafeta, Aïda
• Baudry, Julia
• Bollig, Claudia
• Bonnet, Hillary
• Bouet, Marinette
• Cabanac, Guillaume
• Chaimani, Anna
• Chavalarias, David
• Chen, Yaolong
• Chevance, Astrid
• Coquery, Emmanuel
• Conil, Francoise
• Davidson, Mauricia
• De Nale, Laura
• Devane, Declan
• Diard, Elise
• Doreau, Bastien
• Evrenoglou, Theodoros
• Fabri, Alice
• Feron, Gilles
• Fezeu, Leopold
• Fouet, Mathilde
• El Chall, Lina Ghosn
• Graña, Carolina
• Grasselli, Giacomo
• Grolleau, François
• Hacid, Mohand-Said
• Haddy, Loubna
• Hansen, Camilla
• Hohlfeld, Ameer
• Hróbjartsson, Asbjørn
• Julia, Chantal
• Mavridis, Dimitris
• Meerpohl, Joerg J.
• Meyer, Brice
• Naidoo, Nivantha
• Thu, Van Nguyen
• Oikonomidi, Theodora
• Pienaar, Elizabeth
• Quirke, Fiona
• Rada, Gabriel
• Riveros, Carolina
• Sauvant, Marie
• Schmucker, Christine
• Toumani, Farouk
• Tovey, David
• Xia, Jun
• Yu, Xuan
• Zoletic, Emina
• Zweigenbaum, Pierre

Titel

Research response to coronavirus disease 2019 needed better coordination and collaboration: a living mapping of registered trials

Ist Teil von

• Journal of clinical epidemiology, 2021-02, Vol.130, p.107-116

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2021

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Researchers worldwide are actively engaging in research activities to search for preventive and therapeutic interventions against coronavirus disease 2019 (COVID-19). Our aim was to describe the planning of randomized controlled trials (RCTs) in terms of timing related to the course of the COVID-19 epidemic and research question evaluated. We performed a living mapping of RCTs registered in the WHO International Clinical Trials Registry Platform. We systematically search the platform every week for all RCTs evaluating preventive interventions and treatments for COVID-19 and created a publicly available interactive mapping tool at https://covid-nma.com to visualize all trials registered. By August 12, 2020, 1,568 trials for COVID-19 were registered worldwide. Overall, the median ([Q1–Q3]; range) delay between the first case recorded in each country and the first RCT registered was 47 days ([33–67]; 15–163). For the 9 countries with the highest number of trials registered, most trials were registered after the peak of the epidemic (from 100% trials in Italy to 38% in the United States). Most trials evaluated treatments (1,333 trials; 85%); only 223 (14%) evaluated preventive strategies and 12 postacute period intervention. A total of 254 trials were planned to assess different regimens of hydroxychloroquine with an expected sample size of 110,883 patients. This living mapping analysis showed that COVID-19 trials have relatively small sample size with certain redundancy in research questions. Most trials were registered when the first peak of the pandemic has passed. •Thousands of trials have been planned to identify treatments and preventive interventions for coronavirus disease 2019 (COVID-19).•Decision makers and researchers need to have an overview of all research efforts to avoid overlap.•We create an interactive living mapping of clinical trials of COVID-19 to support these stakeholders in decision-making.