Details

Autor(en) / Beteiligte

• Rydyznski Moderbacher, Carolyn
• Ramirez, Sydney I.
• Dan, Jennifer M.
• Grifoni, Alba
• Hastie, Kathryn M.
• Weiskopf, Daniela
• Belanger, Simon
• Abbott, Robert K.
• Kim, Christina
• Choi, Jinyong
• Kato, Yu
• Crotty, Eleanor G.
• Kim, Cheryl
• Rawlings, Stephen A.
• Mateus, Jose
• Tse, Long Ping Victor
• Frazier, April
• Baric, Ralph
• Peters, Bjoern
• Greenbaum, Jason
• Ollmann Saphire, Erica
• Smith, Davey M.
• Sette, Alessandro
• Crotty, Shane

Titel

Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity

Ist Teil von

• Cell, 2020-11, Vol.183 (4), p.996-1012.e19

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• Limited knowledge is available on the relationship between antigen-specific immune responses and COVID-19 disease severity. We completed a combined examination of all three branches of adaptive immunity at the level of SARS-CoV-2-specific CD4+ and CD8+ T cell and neutralizing antibody responses in acute and convalescent subjects. SARS-CoV-2-specific CD4+ and CD8+ T cells were each associated with milder disease. Coordinated SARS-CoV-2-specific adaptive immune responses were associated with milder disease, suggesting roles for both CD4+ and CD8+ T cells in protective immunity in COVID-19. Notably, coordination of SARS-CoV-2 antigen-specific responses was disrupted in individuals ≥ 65 years old. Scarcity of naive T cells was also associated with aging and poor disease outcomes. A parsimonious explanation is that coordinated CD4+ T cell, CD8+ T cell, and antibody responses are protective, but uncoordinated responses frequently fail to control disease, with a connection between aging and impaired adaptive immune responses to SARS-CoV-2. [Display omitted] •Adaptive immune responses limit COVID-19 disease severity•Multiple coordinated arms of adaptive immunity control better than partial responses•CXCL10 may be a biomarker of impaired T cell responses in acute COVID-19•Aging and scarcity of naive T cells may be linked risk factors for severe COVID-19 Analysis of SARS-CoV-2-specific adaptive immune responses during acute COVID-19 identifies coordination between SARS-CoV-2-specific CD4 T cells and CD8 T cells to limit disease severity. Aged individuals often exhibit uncoordinated adaptive responses, potentially tied to scarcity of naive T cells, highlighting immunologic risk factors linked to disease severity.