European journal of clinical microbiology & infectious diseases, 2020-09, Vol.39 (9), p.1629-1635
2020
Details
- Autor(en) / Beteiligte
- Titel
- The genetic sequence, origin, and diagnosis of SARS-CoV-2
- Ist Teil von
- European journal of clinical microbiology & infectious diseases, 2020-09, Vol.39 (9), p.1629-1635
- Ort / Verlag
- Berlin/Heidelberg: Springer Berlin Heidelberg
- Erscheinungsjahr
- 2020
- Link zum Volltext
- Quelle
- SpringerNature Journals
- Beschreibungen/Notizen
- Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a new infectious disease that first emerged in Hubei province, China, in December 2019, which was found to be associated with a large seafood and animal market in Wuhan. Airway epithelial cells from infected patients were used to isolate a novel coronavirus, named the SARS-CoV-2, on January 12, 2020, which is the seventh member of the coronavirus family to infect humans. Phylogenetic analysis of full-length genome sequences obtained from infected patients showed that SARS-CoV-2 is similar to severe acute respiratory syndrome coronavirus (SARS-CoV) and uses the same cell entry receptor, angiotensin-converting enzyme 2 (ACE2), as SARS-CoV. The possible person-to-person disease rapidly spread to many provinces in China as well as other countries. Without a therapeutic vaccine or specific antiviral drugs, early detection and isolation become essential against novel Coronavirus. In this review, we introduced current diagnostic methods and criteria for the SARS-CoV-2 in China and discuss the advantages and limitations of the current diagnostic methods, including chest imaging and laboratory detection.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0934-9723eISSN: 1435-4373DOI: 10.1007/s10096-020-03899-4Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7180649
- Format
- –
- Schlagworte
- ACE2, Alanine Transaminase - metabolism, Angiotensin, Angiotensin-converting enzyme 2, Animals, Antibodies, Viral - blood, Antiviral agents, Betacoronavirus - genetics, Biomedical and Life Sciences, Biomedicine, C-Reactive Protein - metabolism, China, Chiroptera - virology, Clinical Laboratory Techniques, Coronaviridae, Coronavirus - genetics, Coronavirus Envelope Proteins, Coronavirus Infections - diagnosis, Coronavirus Infections - metabolism, Coronavirus Infections - transmission, Coronavirus Nucleocapsid Proteins, Coronavirus RNA-Dependent RNA Polymerase, Coronaviruses, COVID-19, COVID-19 Testing, COVID-19 Vaccines, Cytokines - metabolism, Diagnostic systems, Epithelial cells, Ferritins - metabolism, Fibrin Fibrinogen Degradation Products - metabolism, Gene sequencing, Genome, Viral - genetics, Genomes, Humans, Immunoglobulin G - immunology, Infectious diseases, Internal Medicine, L-Lactate Dehydrogenase - metabolism, Leukopenia, Lung - diagnostic imaging, Lymphopenia, Medical Microbiology, Nucleocapsid Proteins - genetics, Pandemics, Peptidyl-dipeptidase A, Phosphoproteins, Phylogeny, Pneumonia, Viral - diagnosis, Pneumonia, Viral - metabolism, Pneumonia, Viral - transmission, Polyproteins, Real-Time Polymerase Chain Reaction, Respiratory diseases, Reverse Transcriptase Polymerase Chain Reaction, Review, RNA-Dependent RNA Polymerase - genetics, SARS Virus - genetics, SARS-CoV-2, Seafood, Sensitivity and Specificity, Severe acute respiratory syndrome, Severe acute respiratory syndrome coronavirus 2, Spike Glycoprotein, Coronavirus - genetics, Tomography, X-Ray Computed, Vaccines, Viral diseases, Viral Envelope Proteins - genetics, Viral Nonstructural Proteins - genetics, Viral Proteins - genetics