Details

Autor(en) / Beteiligte

• Sears, Catherine R
• Peikert, Tobias
• Possick, Jennifer D
• Naidoo, Jarushka
• Nishino, Mizuki
• Patel, Sandip P
• Camus, Philippe
• Gaga, Mina
• Garon, Edward B
• Gould, Michael K
• Limper, Andrew H
• Montgrain, Philippe R
• Travis, William D
• Rivera, M Patricia

Titel

Knowledge Gaps and Research Priorities in Immune Checkpoint Inhibitor-related Pneumonitis. An Official American Thoracic Society Research Statement

Ist Teil von

• American journal of respiratory and critical care medicine, 2019-09, Vol.200 (6), p.e31-e43

Ort / Verlag

United States: American Thoracic Society

Erscheinungsjahr

2019

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Immune checkpoint inhibitors (ICIs) have revolutionized cancer care but are associated with unique adverse events, including potentially life-threatening pneumonitis. The diagnosis of ICI-pneumonitis is increasing; however, the biological mechanisms, clinical and radiologic features, and the diagnosis and management have not been well defined. To summarize evidence, identify knowledge and research gaps, and prioritize topics and propose methods for future research on ICI-pneumonitis. A multidisciplinary group of international clinical researchers reviewed available data on ICI-pneumonitis to develop and refine research questions pertaining to ICI-pneumonitis. This statement identifies gaps in knowledge and develops potential research questions to further expand knowledge regarding risk, biologic mechanisms, clinical and radiologic presentation, and management of ICI-pneumonitis. Gaps in knowledge of the basic biological mechanisms of ICI-pneumonitis, coupled with a precipitous increase in the use of ICIs alone or combined with other therapies, highlight the importance in triaging research priorities for ICI-pneumonitis.