Details

Autor(en) / Beteiligte

• Chumsri, Saranya
• Serie, Daniel J
• Li, Zhuo
• Pogue-Geile, Katherine L
• Soyano-Muller, Aixa E
• Mashadi-Hossein, Afshin
• Warren, Sarah
• Lou, Yanyan
• Colon-Otero, Gerardo
• Knutson, Keith L
• Perez, Edith A
• Moreno-Aspitia, Alvaro
• Thompson, E Aubrey

Titel

Effects of Age and Immune Landscape on Outcome in HER2-Positive Breast Cancer in the NCCTG N9831 (Alliance) and NSABP B-31 (NRG) Trials

Ist Teil von

• Clinical cancer research, 2019-07, Vol.25 (14), p.4422-4430

Ort / Verlag

United States

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• Young age has been shown to be an independent predictor of poor outcome in breast cancer. In HER2-positive breast cancer, the effects of aging remain largely unknown. A total of 4,547 patients were included [3,132 from North Central Cancer Treatment Group (NCCTG) N9831 and 1,415 from National Surgical Adjuvant Breast and Bowel Project (NSABP) B-31]. Pathologic stromal tumor-infiltrating lymphocyte (sTIL) and molecular tumor infiltrating lymphocyte (mTIL) signatures were evaluated. In NCCTG N9831, comparable benefit of trastuzumab was observed in all patients [age ≤ 40; HR, 0.43; 95% confidence interval (CI), 0.28-0.66; < 0.001; and age > 40; HR, 0.56; 95% CI, 0.45-0.69; < 0.001]. Similar results were observed in NSABP B-31 (age ≤ 40; HR, 0.45; 95% CI, 0.29-0.68; < 0.001; and age > 40; HR, 0.42; 95% CI, 0.33-0.54; < 0.001). Among patients who received chemotherapy alone, younger age was associated with poor outcome in the hormone receptor-positive subset, but not the hormone receptor-negative subset, in both trials. Although there was no association between sTILs and age, a small, but significant increase in mTIL CD45 and some immune subset signatures were observed. Among patients who received chemotherapy alone, patients over 40 years of age with lymphocyte-predominant breast cancer had excellent outcome, with 95% remaining recurrence free at 15 years. Among patients treated with trastuzumab, there was no significant difference in outcome related to age. Our study suggests that trastuzumab can negate the poor prognosis associated with young age.