Details

Autor(en) / Beteiligte

• Rasmussen, Kirsten
• Rauscher, Hubert
• Kearns, Peter
• González, Mar
• Riego Sintes, Juan

Titel

Developing OECD test guidelines for regulatory testing of nanomaterials to ensure mutual acceptance of test data

Ist Teil von

• Regulatory toxicology and pharmacology, 2019-06, Vol.104, p.74-83

Ort / Verlag

Netherlands: Elsevier Inc

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• The OECD Working Party on Manufactured Nanomaterials (WPMN) provides a global forum for discussion of nano-safety issues. Together with the OECD Test Guidelines Programme (TGP) the WPMN has explored the need for adaptation of some of the existing OECD Test Guidelines (TGs) and Guidance Documents (GDs) as well as developing new TGs and GDs to specifically address NM issues. An overview is provided of progress in the TGP and WPMN, and information on supporting initiatives, regarding the development of TGs for nanomaterials addressing Physical Chemical Properties, Effects on Biotic Systems, Environmental Fate and Behaviour, and Health Effects. Three TGs specifically addressing manufactured nanomaterials have been adopted: a new TG318 ″Dispersion Stability of Nanomaterials in Simulated Environmental Media”, and adaptation of TG412 and TG413 on Subacute Inhalation Toxicity: 28-Day Study/90-day Study. The associated GD39 on Inhalation Toxicity Testing has also been revised. The TGP current develops four new TGs and four GDs. One new TG and six GDs are developed in the WPMN. Six new proposals were submitted to the TGP in 2018. Furthermore, as TGs are accompanied by OECD harmonised templates (OHTs) for data collection, an outline of recently developed OHTs particularly relevant for NMs is also included. •OECD test guidelines are being adapted to ensure the applicability to nanomaterials.•The development of test guidelines has been prioritised.•The test guidelines for inhalation toxicity have been adapted and published.•Several new OECD test guidelines for nano-relevant properties are being developed.