Details

Autor(en) / Beteiligte

• Givens, Brittany E.
• Naguib, Youssef W.
• Geary, Sean M.
• Devor, Eric J.
• Salem, Aliasger K.

Titel

Nanoparticle-Based Delivery of CRISPR/Cas9 Genome-Editing Therapeutics

Ist Teil von

• The AAPS journal, 2018-10, Vol.20 (6), p.108-108, Article 108

Ort / Verlag

Cham: Springer International Publishing

Erscheinungsjahr

2018

Link zum Volltext

Quelle

SpringerLink (Online service)

Beschreibungen/Notizen

• The recent progress in harnessing the efficient and precise method of DNA editing provided by CRISPR/Cas9 is one of the most promising major advances in the field of gene therapy. However, the development of safe and optimally efficient delivery systems for CRISPR/Cas9 elements capable of achieving specific targeting of gene therapy to the location of interest without off-target effects is a primary challenge for clinical therapeutics. Nanoparticles (NPs) provide a promising means to meet such challenges. In this review, we present the most recent advances in developing innovative NP-based delivery systems that efficiently deliver CRISPR/Cas9 constructs and maximize their effectiveness.