Details

Autor(en) / Beteiligte

• Bottecchia, Cecilia
• Noël, Timothy

Titel

Photocatalytic Modification of Amino Acids, Peptides, and Proteins

Ist Teil von

• Chemistry : a European journal, 2019-01, Vol.25 (1), p.26-42

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2019

Quelle

Wiley Blackwell Single Titles

Beschreibungen/Notizen

• In the last decade, visible‐light photoredox catalysis has emerged as a powerful strategy to enable novel transformations in organic synthesis. Owing to mild reaction conditions (i.e., room temperature, use of visible light) and high functional‐group tolerance, photoredox catalysis could represent an ideal strategy for chemoselective biomolecule modification. Indeed, a recent trend in photoredox catalysis is its application to the development of novel methodologies for amino acid modification. Herein, an up‐to‐date overview of photocatalytic methodologies for the modification of single amino acids, peptides, and proteins is provided. The advantages offered by photoredox catalysis and its suitability in the development of novel biocompatible methodologies are described. In addition, a brief consideration of the current limitations of photocatalytic approaches, as well as future challenges to be addressed, are discussed. Shining a light on bioconjugation: In the last decade, photoredox catalysis has emerged as a powerful strategy for novel chemical transformations (see figure). Owing to mild reaction conditions and high selectivities, photoredox catalysis has recently been recognized as a suitable approach for biomolecule modification. In this review, an overview of photoredox methodologies for the modification of amino acids, peptides, and proteins is presented.