Internal Medicine, 2018/11/01, Vol.57(21), pp.3135-3139
2018
Details
- Autor(en) / Beteiligte
- Titel
- The Analysis of Renal Infiltrating Cells in Acute Tubulointerstitial Nephritis Induced by Anti-PD-1 Antibodies: A Case Report and Review of the Literature
- Ist Teil von
- Internal Medicine, 2018/11/01, Vol.57(21), pp.3135-3139
- Ort / Verlag
- Japan: The Japanese Society of Internal Medicine
- Erscheinungsjahr
- 2018
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Nivolumab is an anti-programmed cell death-1 (PD-1) antibody that is utilized as an immune checkpoint inhibitor (ICI) for cancer therapy. We herein present the case of a 57-year-old man who developed acute kidney injury during treatment with nivolumab for lung cancer. A renal biopsy revealed acute tubulointerstitial nephritis. Immunohistochemical staining demonstrated marked infiltration of macrophages and T cells together with mild B cell infiltration. Of note, strong CD163+ M2 macrophage infiltration was observed. The cessation of nivolumab and high-dose prednisolone therapy improved the renal function of the patient. Further, we review the pertinent literature on renal-infiltrating cells in ICI-induced tubulointerstitial nephritis.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0918-2918eISSN: 1349-7235DOI: 10.2169/internalmedicine.0444-17Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6262704
- Format
- –
- Schlagworte
- Acute Kidney Injury - chemically induced, Acute Kidney Injury - drug therapy, Acute Kidney Injury - immunology, Acute Kidney Injury - pathology, acute tubulointerstitial nephritis, anti-PD-1 antibody, Antibodies - immunology, Antigens, CD - immunology, Antigens, Differentiation, Myelomonocytic - immunology, Antineoplastic Agents, Immunological - adverse effects, Antineoplastic Agents, Immunological - immunology, Apoptosis, B-Lymphocytes - immunology, B-Lymphocytes - pathology, B7-H1 Antigen - antagonists & inhibitors, B7-H1 Antigen - immunology, Biopsy, Case Report, CD163 antigen, Cell death, Humans, immune checkpoint inhibitor, Immunologic Factors - therapeutic use, Infiltration, Kidney - immunology, Kidney - pathology, Literature reviews, Lung cancer, Lung Neoplasms - drug therapy, Lymphocytes, Lymphocytes B, Lymphocytes T, M2 macrophage, Macrophages, Macrophages - immunology, Macrophages - pathology, Male, Middle Aged, Monoclonal antibodies, Nephritis, Nephritis, Interstitial - chemically induced, Nephritis, Interstitial - drug therapy, Nephritis, Interstitial - immunology, Nephritis, Interstitial - pathology, Nivolumab - adverse effects, Nivolumab - immunology, PD-1 protein, Prednisolone, Prednisolone - therapeutic use, Programmed Cell Death 1 Receptor, Receptors, Cell Surface - immunology, Renal function, T-Lymphocytes - immunology, T-Lymphocytes - pathology, Targeted cancer therapy