Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Ergebnis 16 von 80

Details

Autor(en) / Beteiligte
Titel
Biological interactions of biocompatible and water-dispersed MoS2 nanosheets with bacteria and human cells
Ist Teil von
  • Scientific reports, 2018-11, Vol.8 (1), p.1-15, Article 16386
Ort / Verlag
London: Nature Publishing Group
Erscheinungsjahr
2018
Link zum Volltext
Quelle
Elektronische Zeitschriftenbibliothek (Open access)
Beschreibungen/Notizen
  • Abstract Two dimensional materials beyond graphene such as MoS 2 and WS 2 are novel and interesting class of materials whose unique physico-chemical properties can be exploited in applications ranging from leading edge nanoelectronics to the frontiers between biomedicine and biotechnology. To unravel the potential of TMD crystals in biomedicine, control over their production through green and scalable routes in biocompatible solvents is critically important. Furthermore, considering multiple applications of eco-friendly 2D dispersions and their potential impact onto live matter, their toxicity and antimicrobial activity still remain an open issue. Herein, we focus on the current demands of 2D TMDs and produce high-quality, few-layered and defect-free MoS 2 nanosheets, exfoliated and dispersed in pure water, stabilized up to three weeks. Hence, we studied the impact of this material on human cells by investigating its interactions with three cell lines: two tumoral, MCF7 (breast cancer) and U937 (leukemia), and one normal, HaCaT (epithelium). We observed novel and intriguing results, exhibiting evident cytotoxic effect induced in the tumor cell lines, absent in the normal cells in the tested conditions. The antibacterial action of MoS 2 nanosheets is then investigated against a very dangerous gram negative bacterium, such as two types of Salmonellas : ATCC 14028 and wild-type Salmonella typhimurium . Additionally, concentration and layer-dependent modulation of cytotoxic effect is found both on human cells and Salmonellas .
Sprache
Englisch
Identifikatoren
ISSN: 2045-2322
eISSN: 2045-2322
DOI: 10.1038/s41598-018-34679-y
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6219585

Weiterführende Literatur

Empfehlungen zum selben Thema automatisch vorgeschlagen von bX