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The prognostic role of sex, race, and human papillomavirus in oropharyngeal and nonoropharyngeal head and neck squamous cell cancer
Cancer, 2017-05, Vol.123 (9), p.1566-1575
Fakhry, Carole
Westra, William H.
Wang, Steven J.
van Zante, Annemieke
Zhang, Yuehan
Rettig, Eleni
Yin, Linda X.
Ryan, William R.
Ha, Patrick K.
Wentz, Alicia
Koch, Wayne
Richmon, Jeremy D.
Eisele, David W.
D'Souza, Gypsyamber
2017
Details
Autor(en) / Beteiligte
Fakhry, Carole
Westra, William H.
Wang, Steven J.
van Zante, Annemieke
Zhang, Yuehan
Rettig, Eleni
Yin, Linda X.
Ryan, William R.
Ha, Patrick K.
Wentz, Alicia
Koch, Wayne
Richmon, Jeremy D.
Eisele, David W.
D'Souza, Gypsyamber
Titel
The prognostic role of sex, race, and human papillomavirus in oropharyngeal and nonoropharyngeal head and neck squamous cell cancer
Ist Teil von
Cancer, 2017-05, Vol.123 (9), p.1566-1575
Ort / Verlag
United States: Wiley Subscription Services, Inc
Erscheinungsjahr
2017
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
BACKGROUND Human papillomavirus (HPV) is a well‐established prognostic marker for oropharyngeal squamous cell cancer (OPSCC). Because of the limited numbers of women and nonwhites in studies to date, sex and racial/ethnic differences in prognosis have not been well explored. In this study, survival differences were explored by the tumor HPV status among 1) patients with OPSCCs by sex and race and 2) patients with nonoropharyngeal (non‐OP) head and neck squamous cell cancers (HNSCCs). METHODS This retrospective, multi‐institution study included OPSCCs and non‐OP HNSCCs of the oral cavity, larynx, and nasopharynx diagnosed from 1995 to 2012. Race/ethnicity was categorized as white non‐Hispanic, black non‐Hispanic, Asian non‐Hispanic, and Hispanic of any race. Tumors were centrally tested for p16 overexpression and the presence of HPV by HPV16 DNA and high‐risk HPV E6/E7 messenger RNA in situ hybridization. Kaplan‐Meier and Cox proportional hazards models were used to evaluate overall survival (OS). RESULTS The study population included 239 patients with OPSCC and 621 patients with non‐OP HNSCC with a median follow‐up time of 3.5 years. After adjustments for the tumor HPV status, age, current tobacco use, and stage, the risk of death was lower for women versus men with OPSCC (adjusted hazard ratio, 0.55; P = .04). The results were similar with p16. In contrast, for non‐OP HNSCCs, HPV positivity, p16 positivity, and sex were not associated with OS. CONCLUSIONS For OPSCC, there are differences in survival by sex, even after the tumor HPV status has been taken into account. For non‐OP HNSCC, the HPV status and the p16 status are not of prognostic significance. Cancer 2017;123:1566–1575. © 2017 American Cancer Society. Among patients with oropharyngeal squamous cell cancer, the risk of death is reduced not only with human papillomavirus positivity (adjusted hazard ratio, 0.44; P = .007) but also for women versus men (adjusted hazard ratio, 0.55; P = .04). In contrast, among patients with nonoropharyngeal head and neck squamous cell cancer, the human papillomavirus tumor status (P = .77), p16 status (P = .26), and sex (P = .35) have no impact on overall survival. See also pages 1486‐7.
Sprache
Englisch
Identifikatoren
ISSN: 0008-543X
eISSN: 1097-0142
DOI: 10.1002/cncr.30353
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5788020
Format
–
Schlagworte
Adjustment
,
African Americans - statistics & numerical data
,
Asian Americans - statistics & numerical data
,
Cancer
,
Carcinoma, Squamous Cell - ethnology
,
Carcinoma, Squamous Cell - mortality
,
Carcinoma, Squamous Cell - pathology
,
Carcinoma, Squamous Cell - virology
,
Cyclin-Dependent Kinase Inhibitor p16 - metabolism
,
Deoxyribonucleic acid
,
DNA
,
DNA, Viral
,
Ethnic Groups - statistics & numerical data
,
European Continental Ancestry Group - statistics & numerical data
,
Female
,
Hazards
,
Head
,
Head and neck cancer
,
Head and Neck Neoplasms - ethnology
,
Head and Neck Neoplasms - mortality
,
Head and Neck Neoplasms - pathology
,
Head and Neck Neoplasms - virology
,
head and neck squamous cell cancer (HNSCC)
,
Health hazards
,
Health risk assessment
,
Health risks
,
Hispanic Americans - statistics & numerical data
,
Hispanic people
,
Human papillomavirus
,
human papillomavirus (HPV)
,
Human papillomavirus 16 - genetics
,
Human papillomavirus 16 - metabolism
,
Humans
,
Laryngeal Neoplasms - ethnology
,
Laryngeal Neoplasms - mortality
,
Laryngeal Neoplasms - pathology
,
Laryngeal Neoplasms - virology
,
Larynx
,
Male
,
Medical prognosis
,
Men
,
Minority & ethnic groups
,
Mortality
,
Mouth Neoplasms - ethnology
,
Mouth Neoplasms - mortality
,
Mouth Neoplasms - pathology
,
Mouth Neoplasms - virology
,
mRNA
,
Nasopharyngeal Neoplasms - ethnology
,
Nasopharyngeal Neoplasms - mortality
,
Nasopharyngeal Neoplasms - pathology
,
Nasopharyngeal Neoplasms - virology
,
Nasopharynx
,
Neoplasm Staging
,
Oncogene Proteins, Viral - metabolism
,
Oral cavity
,
Oropharyngeal Neoplasms - ethnology
,
Oropharyngeal Neoplasms - mortality
,
Oropharyngeal Neoplasms - pathology
,
Oropharyngeal Neoplasms - virology
,
oropharyngeal squamous cell cancer (OPSCC)
,
p16
,
Papillomaviridae
,
Papillomavirus E7 Proteins - metabolism
,
Papillomavirus Infections - epidemiology
,
Papillomavirus Infections - virology
,
Patients
,
Population studies
,
Prognosis
,
Proportional Hazards Models
,
Race
,
Repressor Proteins - metabolism
,
Retrospective Studies
,
Ribonucleic acid
,
Risk
,
RNA
,
Sex
,
Sex Factors
,
Squamous cell carcinoma
,
Squamous Cell Carcinoma of Head and Neck
,
Survival
,
Tobacco
,
Tumors
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