Details

Autor(en) / Beteiligte

• Kim, Christina K.
• Ye, Li
• Jennings, Joshua H.
• Pichamoorthy, Nandini
• Tang, Daniel D.
• Yoo, Ai-Chi W.
• Ramakrishnan, Charu
• Deisseroth, Karl

Titel

Molecular and Circuit-Dynamical Identification of Top-Down Neural Mechanisms for Restraint of Reward Seeking

Ist Teil von

• Cell, 2017-08, Vol.170 (5), p.1013-1027.e14

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Reward-seeking behavior is fundamental to survival, but suppression of this behavior can be essential as well, even for rewards of high value. In humans and rodents, the medial prefrontal cortex (mPFC) has been implicated in suppressing reward seeking; however, despite vital significance in health and disease, the neural circuitry through which mPFC regulates reward seeking remains incompletely understood. Here, we show that a specific subset of superficial mPFC projections to a subfield of nucleus accumbens (NAc) neurons naturally encodes the decision to initiate or suppress reward seeking when faced with risk of punishment. A highly resolved subpopulation of these top-down projecting neurons, identified by 2-photon Ca2+ imaging and activity-dependent labeling to recruit the relevant neurons, was found capable of suppressing reward seeking. This natural activity-resolved mPFC-to-NAc projection displayed unique molecular-genetic and microcircuit-level features concordant with a conserved role in the regulation of reward-seeking behavior, providing cellular and anatomical identifiers of behavioral and possible therapeutic significance. [Display omitted] •Projections from mPFC exhibit unique molecular and laminar phenotypes•Ca2+ imaging reveals that mPFC→NAc shock neurons encode restraint of reward seeking•vCAPTURE for robust labeling of mPFC→NAc axons active during shock•Stimulating previously active mPFC→NAc shock neurons can reduce reward seeking A population of projection neurons encodes the decision to initiate or suppress reward seeking when faced with punishment.