Details

Autor(en) / Beteiligte

• Surmeier, D James
• Obeso, José A
• Halliday, Glenda M

Titel

Parkinson's Disease Is Not Simply a Prion Disorder

Ist Teil von

• The Journal of neuroscience, 2017-10, Vol.37 (41), p.9799-9807

Ort / Verlag

United States: Society for Neuroscience

Erscheinungsjahr

2017

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The notion that prion-like spreading of misfolded α-synuclein (α-SYN) causes Parkinson's disease (PD) has received a great deal of attention. Although attractive in its simplicity, the hypothesis is difficult to reconcile with postmortem analysis of human brains and connectome-mapping studies. An alternative hypothesis is that PD pathology is governed by regional or cell-autonomous factors. Although these factors provide an explanation for the pattern of neuronal loss in PD, they do not readily explain the apparently staged distribution of Lewy pathology in many PD brains, the feature of the disease that initially motivated the spreading hypothesis by Braak and colleagues. While each hypothesis alone has its shortcomings, a synthesis of the two can explain much of what we know about the etiopathology of PD. Prying into the Prion Hypothesis for Parkinson's Disease, by Patrik Brundin and Ronald Melki.