Details

Autor(en) / Beteiligte

• Colwell, Nicole
• Larion, Mioara
• Giles, Amber J
• Seldomridge, Ashlee N
• Sizdahkhani, Saman
• Gilbert, Mark R
• Park, Deric M

Titel

Hypoxia in the glioblastoma microenvironment: shaping the phenotype of cancer stem-like cells

Ist Teil von

• Neuro-oncology (Charlottesville, Va.), 2017-07, Vol.19 (7), p.887-896

Ort / Verlag

England: Oxford University Press

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Glioblastoma is the most common and aggressive malignant primary brain tumor. Cellular heterogeneity is a characteristic feature of the disease and contributes to the difficulty in formulating effective therapies. Glioma stem-like cells (GSCs) have been identified as a subpopulation of tumor cells that are thought to be largely responsible for resistance to treatment. Intratumoral hypoxia contributes to maintenance of the GSCs by supporting the critical stem cell traits of multipotency, self-renewal, and tumorigenicity. This review highlights the interaction of GSCs with the hypoxic tumor microenvironment, exploring the mechanisms underlying the contribution of GSCs to tumor vessel dynamics, immune modulation, and metabolic alteration.